| Effects of statin therapy on inflammatory markers in chronic heart failure: a meta-analysis of randomized controlled trials. | |
| | |
MedLine Citation:
|
PMID: 21044751 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND AND AIMS: Inflammation is thought to be important in mediating the progression of chronic heart failure (CHF). Whether beneficial effects on inflammation can be achieved by statins in patients with CHF remains uncertain. This meta-analysis was conducted to determine the role of statin therapy in inflammation markers in CHF patients. METHODS: Pubmed, MEDLINE, EMBASE, and EBM Reviews databases were searched for randomized controlled trials comparing statin treatment with non-statin treatment in CHF patients. Two reviews independently assessed studies and extracted data. Standardized mean differences (SMD) were calculated using random effects models. RESULTS: Ten studies with 6052 patients were included. Pooled analysis showed that statin therapy was associated with significant decrease in high-sensitivity C-reactive protein (SMD = -0.74, 95% CI -1.16 to -0.32; p = 0.0005) and soluble vascular cell adhesion molecule-1 (SMD = -0.49, 95% CI -0.91 to -0.08; p = 0.02). However, the beneficial effects of statin were not shown regarding interleukin-6 (SMD = -0.85, 95% CI -2.09 to 0.38; p = 0.18) and tumor necrosis factor-α (SMD = -0.13, 95% CI -0.50 to 0.25; p = 0.51). Sources of heterogeneity were not found by meta-regression analyses, whereas subgroup analyses showed that difference in age, etiology, baseline left ventricular ejection fraction, type of statins and follow-up duration might influence the effects of statins. CONCLUSIONS: Statin may partially suppress inflammatory markers in patients with CHF; moreover, this beneficial effect may be associated with different types of statins, treatment intervals and characteristics of patients. |
| | |
Authors:
|
Lei Zhang; Shuning Zhang; Hong Jiang; Aijun Sun; Yunkai Wang; Yunzeng Zou; Junbo Ge; Haozhu Chen |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Archives of medical research Volume: 41 ISSN: 1873-5487 ISO Abbreviation: Arch. Med. Res. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-11-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9312706 Medline TA: Arch Med Res Country: United States |
Other Details:
|
Languages: eng Pagination: 464-71 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 IMSS. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum adiponectin and vaspin levels in rheumatoid arthritis.
Next Document: Influence of CRP, IL6, and TNFA gene polymorphisms on circulating levels of C-reactive protein in Me...