Document Detail

Effects of spray drying on physicochemical properties of chitosan acid salts.
MedLine Citation:
PMID:  21560022     Owner:  NLM     Status:  MEDLINE    
The effects of spray-drying process and acidic solvent system on physicochemical properties of chitosan salts were investigated. Chitosan used in spray dryings was obtained by deacetylation of chitin from lobster (Panulirus argus) origin. The chitosan acid salts were prepared in a laboratory-scale spray drier, and organic acetic acid, lactic acid, and citric acid were used as solvents in the process. The physicochemical properties of chitosan salts were investigated by means of solid-state CP-MAS (13)C nuclear magnetic resonance (NMR), X-ray powder diffraction (XRPD), differential scanning calorimetry, and Fourier transform infrared spectrometry (FTIR) and near-infrared spectroscopy. The morphology of spray-dried chitosan acid salts showed tendency toward higher sphericity when higher temperatures in a spray-drying process were applied. Analysis by XRPD indicated that all chitosan acid salts studied were amorphous solids. Solid-state (13)C NMR spectra revealed the evidence of the partial conversion of chitosan acetate to chitin and also conversion to acetyl amide form which appears to be dependent on the spray-drying process. The FTIR spectra suggested that the organic acids applied in spray drying may interact with chitosan at the position of amino groups to form chitosan salts. With all three chitosan acid salts, the FTIR bands at 1,597 and 1,615 cm(-1) were diminished suggesting that -NH groups are protonated. The FTIR spectra of all chitosan acid salts exhibited ammonium and carboxylate bands at 1,630 and 1,556 cm(-1), respectively. In conclusion, spray drying is a potential method of preparing acid salts from chitosan obtained by deacetylation of chitin from lobster (P. argus) origin.
Mirna Fernández Cervera; Jyrki Heinämäki; Nilia de la Paz; Orestes López; Sirkka Liisa Maunu; Tommi Virtanen; Timo Hatanpää; Osmo Antikainen; Antonio Nogueira; Jorge Fundora; Jouko Yliruusi
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-11
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  12     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-07-13     Completed Date:  2012-05-16     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  637-49     Citation Subset:  IM    
Institute of Pharmacy and Food, University of Havana, La Coronela, La Lisa, Cuba.
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MeSH Terms
Acetic Acid / chemistry*,  standards
Chemistry, Pharmaceutical / methods*,  standards
Chitosan / chemistry*,  isolation & purification,  standards
Lactic Acid / chemistry*,  standards
Particle Size
Salts / chemistry,  standards
Reg. No./Substance:
0/Salts; 0/chitosan citrate; 50-21-5/Lactic Acid; 64-19-7/Acetic Acid; 9012-76-4/Chitosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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