Document Detail

Effects of Soy-derived diets on plasma and liver lipids, glucose tolerance, and longevity in normal, long-lived and short-lived mice.
MedLine Citation:
PMID:  15326565     Owner:  NLM     Status:  MEDLINE    
We examined the effects of diets based on a low isoflavone or a high isoflavone soy protein isolates in normal, growth-hormone receptor knockout and Ames dwarf, and Prop 1 (df) mice that are hypoinsulinemic, insulin-sensitive, and exceptionally long-lived, as well as in growth hormone transgenic mice that are hyperinsulinemic, insulin-resistant, dyslipidemic, and short-lived. Soybean diets tended to normalize plasma cholesterol levels in dwarf and transgenic mice, while low isoflavone diet reduced plasma triglycerides in most of the examined genotypes. The effects of low isoflavone and high isoflavone diets on the levels of free and esterified cholesterol in the liver were strongly genotype-dependent. Fasting blood glucose levels were reduced and glucose tolerance improved by both low isoflavone and high isoflavone diets in growth hormone-transgenic mice and in their normal siblings. Glucose tolerance was also improved by high-isoflavone diet in growth hormone receptor knockout mice. Lifespan was increased by low isoflavone diet in normal mice from two of the examined stocks. High isoflavone diet increased lifespan in normal animals from one line, but reduced lifespan of normal mice from a different line. We conclude that dietary soy protein intake can improve plasma and hepatic lipid profiles, reduce fasting glucose, enhance capacity for glucose tolerance, and prolong life, but all of these effects are strongly genotype-dependent.
A Bartke; M R Peluso; N Moretz; C Wright; M Bonkowski; T A Winters; M F Shanahan; J J Kopchick; W J Banz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  36     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-24     Completed Date:  2005-02-14     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  550-8     Citation Subset:  IM    
Department of Physiology, Southern Illinois University School of Medicine, Springfield 62794-9628, USA.
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MeSH Terms
Blood Glucose / metabolism
Body Weight
Caseins / administration & dosage
Cholesterol / metabolism
Dwarfism / genetics,  metabolism,  physiopathology
Glucose / physiology*
Glucose Tolerance Test
Human Growth Hormone / genetics
Isoflavones / administration & dosage
Lipid Metabolism*
Lipids / blood
Liver / anatomy & histology,  metabolism*
Mice, Inbred Strains
Mice, Knockout
Mice, Transgenic
Organ Size
Osmolar Concentration
Receptors, Somatotropin / deficiency
Soybean Proteins / administration & dosage
Triglycerides / metabolism
Reg. No./Substance:
0/Blood Glucose; 0/Caseins; 0/Isoflavones; 0/Lipids; 0/Receptors, Somatotropin; 0/Soybean Proteins; 0/Triglycerides; 12629-01-5/Human Growth Hormone; 50-99-7/Glucose; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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