| Effects of silodosin and naftopidil on the distal ureter and cardiovascular system in anesthetized dogs: comparison of potential medications for distal ureteral stone passage. | |
| | |
MedLine Citation:
|
PMID: 19914658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: We compared the effects of the selective alpha(1A)-adrenoceptor antagonist silodosin and the selective alpha(1D)-adrenoceptor antagonist naftopidil on intraureteral pressure in anesthetized dogs and evaluated their uroselectivity. MATERIALS AND METHODS: Using anesthesia the effects of silodosin and naftopidil were evaluated by the phenylephrine induced increase in intravesical ureteral pressure and on blood pressure. Each drug was administered intravenously in progressively increasing doses. The dose of each alpha(1)-adrenoceptor antagonist at which mean blood pressure was decreased by 15% (ED(15)) and the dose at which the phenylephrine induced increase in intravesical ureteral pressure was suppressed by 50% (ID(50)) were measured and uroselectivity was calculated as ED(15)/ID(50). RESULTS: Silodosin dose dependently suppressed the phenylephrine induced increase in intravesical ureteral pressure (ID(50) 2.5 microg/kg) but decreased mean blood pressure only at higher doses (ED(15) 143.4 microg/kg). In contrast, naftopidil decreased mean blood pressure (ED(15) 280.7 microg/kg) at the same doses as those that decreased the phenylephrine induced increase in intravesical ureteral pressure (ID(50) 225.1 microg/kg). Silodosin uroselectivity was markedly higher than that of naftopidil (58.6 vs 1.3). CONCLUSIONS: Results suggest that a selective alpha(1A)-adrenoceptor antagonist such as silodosin may facilitate distal ureteral stone passage at nonhypotensive doses. |
| | |
Authors:
|
Shinya Kobayashi; Yoshitaka Tomiyama; Yuji Hoyano; Yoshinobu Yamazaki; Shoichi Sasaki; Kenjiro Kohri |
Related Documents
:
|
2455198 - Role of the central nervous system in human secondary hypertension. 7198468 - The withdrawal of centrally acting antihypertensives in dogs. 3752658 - Reversal of clonidine toxicity by naloxone. 9203168 - Cardiovascular parameters of heroin-withdrawn addicts treated with guanfacine. 14500008 - A high-pressure thermal gradient block for investigating microbial activity in multiple... 1742048 - Effects of prostaglandin e2 on the newborn respiratory system. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of urology Volume: 183 ISSN: 1527-3792 ISO Abbreviation: J. Urol. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-12-16 Completed Date: 2010-01-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
|
Languages: eng Pagination: 357-61 Citation Subset: AIM; IM |
Affiliation:
|
Pharmacology Research and Development, Kissei Pharmaceutical Co Ltd, Nagano, Aichi, Japan. shinya_kobayashi@pharm.kissei.co.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic alpha-Antagonists
/
pharmacology*,
therapeutic use* Anesthesia* Animals Cardiovascular System / drug effects* Dogs Dose-Response Relationship, Drug Indoles / pharmacology*, therapeutic use* Male Naphthalenes / pharmacology*, therapeutic use* Piperazines / pharmacology*, therapeutic use* Ureter / drug effects* Ureteral Calculi / drug therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic alpha-Antagonists; 0/Indoles; 0/KMD 3213; 0/Naphthalenes; 0/Piperazines; 57149-07-2/naftopidil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hypercalciuria is Related to Osmolar Excretion in Children With Nocturnal Enuresis.
Next Document: Comparison of Flank, Dorsal Lumbotomy and Laparoscopic Approaches for Dismembered Pyeloplasty in Chi...