Document Detail


Effects of silodosin and naftopidil on the distal ureter and cardiovascular system in anesthetized dogs: comparison of potential medications for distal ureteral stone passage.
MedLine Citation:
PMID:  19914658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: We compared the effects of the selective alpha(1A)-adrenoceptor antagonist silodosin and the selective alpha(1D)-adrenoceptor antagonist naftopidil on intraureteral pressure in anesthetized dogs and evaluated their uroselectivity.
MATERIALS AND METHODS: Using anesthesia the effects of silodosin and naftopidil were evaluated by the phenylephrine induced increase in intravesical ureteral pressure and on blood pressure. Each drug was administered intravenously in progressively increasing doses. The dose of each alpha(1)-adrenoceptor antagonist at which mean blood pressure was decreased by 15% (ED(15)) and the dose at which the phenylephrine induced increase in intravesical ureteral pressure was suppressed by 50% (ID(50)) were measured and uroselectivity was calculated as ED(15)/ID(50).
RESULTS: Silodosin dose dependently suppressed the phenylephrine induced increase in intravesical ureteral pressure (ID(50) 2.5 microg/kg) but decreased mean blood pressure only at higher doses (ED(15) 143.4 microg/kg). In contrast, naftopidil decreased mean blood pressure (ED(15) 280.7 microg/kg) at the same doses as those that decreased the phenylephrine induced increase in intravesical ureteral pressure (ID(50) 225.1 microg/kg). Silodosin uroselectivity was markedly higher than that of naftopidil (58.6 vs 1.3).
CONCLUSIONS: Results suggest that a selective alpha(1A)-adrenoceptor antagonist such as silodosin may facilitate distal ureteral stone passage at nonhypotensive doses.
Authors:
Shinya Kobayashi; Yoshitaka Tomiyama; Yuji Hoyano; Yoshinobu Yamazaki; Shoichi Sasaki; Kenjiro Kohri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  183     ISSN:  1527-3792     ISO Abbreviation:  J. Urol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-01-06     Revised Date:  2013-05-22    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  357-61     Citation Subset:  AIM; IM    
Affiliation:
Pharmacology Research and Development, Kissei Pharmaceutical Co Ltd, Nagano, Aichi, Japan. shinya_kobayashi@pharm.kissei.co.jp
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / pharmacology*,  therapeutic use*
Anesthesia*
Animals
Cardiovascular System / drug effects*
Dogs
Dose-Response Relationship, Drug
Indoles / pharmacology*,  therapeutic use*
Male
Naphthalenes / pharmacology*,  therapeutic use*
Piperazines / pharmacology*,  therapeutic use*
Ureter / drug effects*
Ureteral Calculi / drug therapy*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Indoles; 0/Naphthalenes; 0/Piperazines; CUZ39LUY82/silodosin; R9PHW59SFN/naftopidil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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