Document Detail

Effects of Short Course Androgen Therapy on the Neurodevelopmental Profile of Infants and Children with 49, XXXXY Syndrome.
MedLine Citation:
PMID:  21362043     Owner:  NLM     Status:  Publisher    
Aim:  The aim of this investigation was to ascertain if an early course of androgen treatment (three injections testosterone enanthate, 25mg) could have a positive impact on any domains of neurodevelopmental function in boys with 49, XXXXY. Methods:  22 boys with a karyotype of 49, XXXXY participated in a multidisciplinary assessment of neurocognition, speech and language, pediatric neurology and endocrinology evaluations. One group had received early androgen and another group did not receive any hormonal treatment prior to the evaluation. The mean age of treatment for Group 1 was 12 months with the mean age of first evaluation 74 months. The mean age of first evaluation for Group 2 was 87 months. Statistical analysis was completed to determine if there was a positive treatment effect from androgen therapy. Results:  There was a significant positive treatment effect in speech and language domain, gestural communication and vocabulary development. No treatment effect was seen on nonverbal capacities. Conclusion:  Our findings revealed improved function in several areas of development which had been severely delayed in boys with 49, XXXXY. Continued research is underway to expand our understanding of the relationship of androgen, brain function and behavioral outcome in boys with 49, XXXXY.
Carole A Samango-Sprouse; Andrea L Gropman; Teresa Sadeghin; Madison Kingery; Margaret Lutz-Armstrong; Alan D Rogol
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-1
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Acta Paediatrica © 2011 Foundation Acta Paediatrica.
George Washington University of the Health Sciences, Washington, D.C. Department of Neurology, Children's National Medical Center Department of Pediatrics, University of Virginia, Charlottesville, VA Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN Neurodevelopmental Diagnostic Center for Young Children, Davidsonville, MD.
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