Document Detail


The effects of severity of oligozoospermia on Intracytoplasmic Sperm Injection (ICSI) cycle outcome.
MedLine Citation:
PMID:  20170289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to explore the relationship between the severity of oligozoospermia and the development of embryos and clinical outcome in patients undergoing ICSI. A total of 908 intracytoplasmic sperm injection cycles involving women of < or =37 years of age were included in this study. The patients were divided into four treatment groups according to the results of an analysis of their husbands' semen: (A) mild oligozoospermia that ranged from 10 x 10(6)/ml to <20 x 10(6)/ml (n=283), (B) mild to severe oligozoospermia that ranged from 5 x 10(6)/ml to <10 x 10(6)/ml (n=192), (C) severe oligospermia that ranged from 1 x10(6)/ml to <5 x 10(6)/ml (n=259), and (D) very severe oligozoospermia that ranged from 0 to <1 x10(6)/ml (n=174). Two pronuclei (PN) oocytes at MII were injected and the development of high quality embryos on day 2, as well blastocyst formation rate on day 5, the implantation rate, clinical pregnancies, and fetal loss, were examined. A lower percentage of two pronuclei (2PN) oocytes in the very severe oligozoospermia group was observed, however, there was no difference in clinical outcome when the oligozoospermic patients were divided by sperm concentration. In addition, no significant difference was detected in zygote production or clinical outcome between spermatozoa with a motility of <40% and spermatozoa with a motility of > or =40%. The results of this study emphasize the importance of selecting good quality sperm for oocyte injection, especially in cases involving very severe oligozoospermia.
Authors:
Hiromi Hashimoto; Tomomoto Ishikawa; Sakae Goto; Shoji Kokeguchi; Masato Fujisawa; Masahide Shiotani
Related Documents :
3300579 - Diagnosis of varicocele and postoperative evaluation using inguinal ultrasonography.
21239939 - Assessment of the functionality of the pectoralis major myocutaneous flap skin paddle.
21509719 - Aspirin does not increase bleeding and allogeneic blood transfusion in coronary artery ...
21173349 - Survival comparison of the ross procedure and mechanical valve replacement with optimal...
18542979 - Histopathological examination of the effects of radiofrequency treatment on mucosa in p...
16340279 - Radiofrequency for the treatment of vasomotor rhinitis.
14765309 - Variceal bleeding and portal hypertension: new lights on old horizon.
23623219 - Postoperative hyponatremia predicts an increase in mortality and in-hospital complicat...
19462169 - Comparative study of the use of electromagnetic fields in patients with pseudoarthrosis...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Systems biology in reproductive medicine     Volume:  56     ISSN:  1939-6376     ISO Abbreviation:  Syst Biol Reprod Med     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101464963     Medline TA:  Syst Biol Reprod Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  91-5     Citation Subset:  IM    
Affiliation:
Hanabusa Women's Clinic and Kobe University Graduate School of Medicine, Kobe, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous
Adult
Embryo Implantation
Female
Humans
Male
Oligospermia / pathology*,  therapy*
Pregnancy
Pregnancy Outcome*
Pregnancy Rate
Semen / cytology,  physiology
Sperm Injections, Intracytoplasmic / methods*
Sperm Motility / physiology
Spermatozoa / pathology*,  physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Follicle-stimulating hormone receptor gene haplotypes and male infertility in estonian population an...
Next Document:  The relationships between high-sensitivity C-reactive protein and incident depressed mood among olde...