Document Detail

The effects of severity of oligozoospermia on Intracytoplasmic Sperm Injection (ICSI) cycle outcome.
MedLine Citation:
PMID:  20170289     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to explore the relationship between the severity of oligozoospermia and the development of embryos and clinical outcome in patients undergoing ICSI. A total of 908 intracytoplasmic sperm injection cycles involving women of < or =37 years of age were included in this study. The patients were divided into four treatment groups according to the results of an analysis of their husbands' semen: (A) mild oligozoospermia that ranged from 10 x 10(6)/ml to <20 x 10(6)/ml (n=283), (B) mild to severe oligozoospermia that ranged from 5 x 10(6)/ml to <10 x 10(6)/ml (n=192), (C) severe oligospermia that ranged from 1 x10(6)/ml to <5 x 10(6)/ml (n=259), and (D) very severe oligozoospermia that ranged from 0 to <1 x10(6)/ml (n=174). Two pronuclei (PN) oocytes at MII were injected and the development of high quality embryos on day 2, as well blastocyst formation rate on day 5, the implantation rate, clinical pregnancies, and fetal loss, were examined. A lower percentage of two pronuclei (2PN) oocytes in the very severe oligozoospermia group was observed, however, there was no difference in clinical outcome when the oligozoospermic patients were divided by sperm concentration. In addition, no significant difference was detected in zygote production or clinical outcome between spermatozoa with a motility of <40% and spermatozoa with a motility of > or =40%. The results of this study emphasize the importance of selecting good quality sperm for oocyte injection, especially in cases involving very severe oligozoospermia.
Hiromi Hashimoto; Tomomoto Ishikawa; Sakae Goto; Shoji Kokeguchi; Masato Fujisawa; Masahide Shiotani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Systems biology in reproductive medicine     Volume:  56     ISSN:  1939-6376     ISO Abbreviation:  Syst Biol Reprod Med     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101464963     Medline TA:  Syst Biol Reprod Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  91-5     Citation Subset:  IM    
Hanabusa Women's Clinic and Kobe University Graduate School of Medicine, Kobe, Japan.
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MeSH Terms
Abortion, Spontaneous
Embryo Implantation
Oligospermia / pathology*,  therapy*
Pregnancy Outcome*
Pregnancy Rate
Semen / cytology,  physiology
Sperm Injections, Intracytoplasmic / methods*
Sperm Motility / physiology
Spermatozoa / pathology*,  physiology

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