| Effects of Sasa Health, extract of bamboo grass leaves, on spontaneous mammary tumourigenesis in SHN mice. | |
| | |
MedLine Citation:
|
PMID: 9568070 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Chronic treatment with Sasa Health, extract of bamboo grass leaves obtained by alkaline hydrolysis, in drinking water at the concentration of 0.044%-0.088% Fe-Chlorophyllin Na resulted in the significant inhibition of both development and growth of spontaneous mammary tumours in a high mammary tumour strain of SHN virgin mice. Limited treatment for 12 days in mice with palpable sizes of mammary tumours also markedly retarded the growth of the tumours. The end-bud formation and thymidylate synthetase activity of normal mammary glands were stimulated, but the formation of preneoplastic mammary hyperplastic alveolar nodules was inhibited by the treatment. Chronic ingestion of Sasa Health stimulated the excretion of urine components and decreased and increased the prolactin level and superoxide dismutase activity in serum, respectively. It showed no deleterious effects on food and water intake, body growth and any external appearance and all findings indicate that Sasa Health could be a promising agent for the protection and therapy of breast and other types of tumours. |
| | |
Authors:
|
S Tsunoda; K Yamamoto; S Sakamoto; H Inoue; H Nagasawa |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Anticancer research Volume: 18 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 1998 Jan-Feb |
Date Detail:
|
Created Date: 1998-05-13 Completed Date: 1998-05-13 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: GREECE |
Other Details:
|
Languages: eng Pagination: 153-8 Citation Subset: IM |
Affiliation:
|
Experimental Animal Research laboratory Meiji University, Kawasaki, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Weight / drug effects Chemoprevention Chlorophyllides / pharmacology* Estrus / drug effects Feeding Behavior / drug effects Female Mammary Glands, Animal / metabolism Mammary Neoplasms, Experimental / prevention & control* Mice Mice, Inbred Strains Organ Size / drug effects Plant Extracts / blood, pharmacology* Poaceae Precancerous Conditions / prevention & control Prolactin / blood RNA, Messenger / genetics RNA, Neoplasm / genetics Superoxide Dismutase / blood Tumor Necrosis Factor-alpha / genetics Uterine Neoplasms / prevention & control |
| Chemical | |
Reg. No./Substance:
|
0/Chlorophyllides; 0/Plant Extracts; 0/RNA, Messenger; 0/RNA, Neoplasm; 0/Tumor Necrosis Factor-alpha; 15611-43-5/chlorophyllin; 9002-62-4/Prolactin; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myocardial infarction induces expression of midkine, a heparin-binding growth factor with reparative...
Next Document: The efficacy of immunochemotherapy with strontium (Sr) in the 1,2-dimethylhydrazine (DMH) induced ra...