| Effects of SA6541, a leukotriene A4 hydrolase inhibitor, and indomethacin on carrageenan-induced murine dermatitis. | |
| | |
MedLine Citation:
|
PMID: 9617756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We investigated the effects of S-(4-dimethylaminobenzyl)-N-[(2S)-3-mercapto-2-methylpropionyl]-L- cysteine (SA6541), a potent leukotriene A4 hydrolase inhibitor. on early phase of carrageenan-induced dermatitis model. Carrageenan injection induced edema and neutrophil influx in the mouse ear. SA6541 inhibited edema formation and neutrophil influx. SA6541 also inhibited leukotriene B4 production but not prostaglandin E2 production in the mouse ear. On the other hand, indomethacin inhibited edema formation but not neutrophil influx. Indomethacin also inhibited prostaglandin E2 production but not leukotriene B4 production. Combination therapy with SA6541 and indomethacin strongly inhibited edema formation in comparison with treatment with either agent alone. These results suggest that leukotriene B4 may be important in the pathogenesis of dermatitis. |
| | |
Authors:
|
F Tsuji; Y Miyake; H Enomoto; M Horiuchi; S Mita |
Related Documents
:
|
2167876 - Lipoxins a4 and b4 inhibit leukotriene b4 generation from human neutrophil leukocyte su... 2549576 - Ovarian follicular fluid eicosanoid concentrations during the pre-ovulatory period in h... 6193056 - Enhancement of human neutrophil adherence by synthetic leukotriene constituents of the ... 2554366 - 1-[4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1- piperidinyl]propoxy]-3-methoxyphenyl]e... 15333406 - The soluble guanylyl cyclase inhibitor odq, 1h-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one... 8460266 - Adp induces desensitisation of equine platelet aggregation responses: studies using adp... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of pharmacology Volume: 346 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1998 Apr |
Date Detail:
|
Created Date: 1998-08-04 Completed Date: 1998-08-04 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 81-5 Citation Subset: IM |
Affiliation:
|
Discovery Research Division, Santen Pharmaceutical, Osaka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aniline Compounds
/
pharmacology* Animals Carrageenan / toxicity* Cysteine / analogs & derivatives*, pharmacology Dermatitis, Contact / metabolism, prevention & control* Edema / prevention & control Enzyme Inhibitors / pharmacology* Epoxide Hydrolases / antagonists & inhibitors* Indomethacin / pharmacology* Leukotriene B4 / antagonists & inhibitors, biosynthesis Male Mice Mice, Inbred ICR |
| Chemical | |
Reg. No./Substance:
|
0/Aniline Compounds; 0/Enzyme Inhibitors; 0/SA 6541; 52-90-4/Cysteine; 53-86-1/Indomethacin; 71160-24-2/Leukotriene B4; 9000-07-1/Carrageenan; EC 3.3.2.-/Epoxide Hydrolases; EC 3.3.2.-/leukotriene A4 hydrolase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bus...
Next Document: Human neuropeptide YY1 receptors exert unequal control of the extracellular acidification rate in di...