| Effects of SA13353, a transient receptor potential vanilloid 1 agonist, on leukocyte infiltration in lipopolysaccharide-induced acute lung injury and ovalbumin-induced allergic airway inflammation. | |
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MedLine Citation:
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PMID: 20351486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We recently demonstrated that SA13353, a transient receptor potential vanilloid 1 (TRPV1) agonist, reduced the severity of the symptoms of kidney injury, arthritis, and encephalomyelitis in disease models. Here, we investigated the effects of orally administered SA13353 on leukocyte infiltration in lipopolysaccharide (LPS)-induced acute lung injury and ovalbumin-induced allergic airway inflammation. In LPS-induced lung injury, SA13353 attenuated neutrophil infiltration and the increase of TNF-alpha and CINC-1 levels. In allergic airway inflammation, SA13353 tended to inhibit leukocyte infiltration and attenuated the increase of IL-4 and IL-12p40. These results suggest that somatosensory TRPV1 may play an anti-inflammatory role in lung inflammation. |
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Authors:
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Fumio Tsuji; Masaaki Murai; Kenji Oki; Hiroyuki Inoue; Minoru Sasano; Hiroyuki Tanaka; Naoki Inagaki; Hiroyuki Aono |
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Publication Detail:
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Type: Journal Article Date: 2010-03-30 |
Journal Detail:
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Title: Journal of pharmacological sciences Volume: 112 ISSN: 1347-8648 ISO Abbreviation: J. Pharmacol. Sci. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-08-12 Revised Date: 2011-06-20 |
Medline Journal Info:
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Nlm Unique ID: 101167001 Medline TA: J Pharmacol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 487-90 Citation Subset: IM |
Affiliation:
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Research and Development Center, Santen Pharmaceutical Co., Ltd., Japan. ftsuji@minuet.plala.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Inflammation / chemically induced* Leukocytes / cytology* Lipopolysaccharides / toxicity* Lung / drug effects*, pathology Mice Ovalbumin / toxicity* Pyridines / pharmacology* TRPV Cation Channels / agonists* Trachea / drug effects*, pathology Urea / analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/1-(2-(1-adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea; 0/Lipopolysaccharides; 0/Pyridines; 0/TRPV Cation Channels; 0/TRPV1 protein, mouse; 57-13-6/Urea; 9006-59-1/Ovalbumin |
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