Document Detail

Effects of (S)-nafenodone, a new antidepressant, in isolated guinea-pig atrial and ventricular muscle fibres.
MedLine Citation:
PMID:  1893926     Owner:  NLM     Status:  MEDLINE    
The electromechanical effects of a new antidepressant, (S)-nafenodone, were studied in isolated guinea-pig atrial and ventricular muscle fibres. In spontaneously beating right atria, (S)-nafenodone decreased the rate and amplitude of contractions and lengthened the sinus node recovery time. In electrically driven atria, the negative inotropic effect of (S)-nafenodone was less marked than that of imipramine and desipramine but similar to that of lofepramine. (S)-Nafenodone had no effect on the resting membrane potential but decreased the amplitude and maximum upstroke velocity (Vmax) both in atrial and ventricular muscle fibres; this effect was less marked than that produced by imipramine and desipramine. In atrial fibres, but not in ventricular fibres, (S)-nafenodone lengthened the action potential duration, but in both tissues it increased the duration of the effective refractory period out of proportion to the change in action potential duration. Moreover, it shifted the concentration-response curve for Ca2+ downwards and decreased the amplitude of the slow atrial contractions induced by histamine as well as the amplitude and Vmax of the slow action potentials induced by isoprenaline in papillary muscles. It is concluded that (S)-nafenodone exerted fewer cardiodepressant effects than imipramine and desipramine in isolated guinea-pig atrial and ventricular muscle fibres less.
F Pérez-Vizcaino; R Carrón; E Delpón; J Tamargo
Related Documents :
19867446 - A few observations on the action of salvarsan upon the irritability of nerve and muscle.
603466 - The origin of the muscle fasciculation caused by funnel-web spider venom.
3097826 - Modulation of smooth muscle responses by serine proteases and related enzymes.
12189126 - Simple experiments to understand the ionic origins and characteristics of the ventricul...
11060216 - Hindlimb extensor muscle function during jumping and swimming in the toad (bufo marinus).
1192606 - Glyoxalase enzyme system in human muscular dystrophy.
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  199     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-10-24     Completed Date:  1991-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  43-50     Citation Subset:  IM    
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Action Potentials / drug effects
Antidepressive Agents / pharmacology*
Calcium / pharmacology
Desipramine / pharmacology
Guinea Pigs
Heart / drug effects*
Heart Atria / drug effects
Heart Ventricles / drug effects
Imipramine / pharmacology
Isoproterenol / pharmacology
Lofepramine / pharmacology
Myocardial Contraction / drug effects
Naphthalenes / pharmacology*
Papillary Muscles / drug effects
Refractory Period, Electrophysiological / drug effects
Reg. No./Substance:
0/Antidepressive Agents; 0/Naphthalenes; 23047-25-8/Lofepramine; 50-47-5/Desipramine; 50-49-7/Imipramine; 7440-70-2/Calcium; 7683-59-2/Isoproterenol; 92629-87-3/nafenodone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Interactions between ibogaine, a potential anti-addictive agent, and morphine: an in vivo microdialy...
Next Document:  Cardiovascular actions of inhibitors of endothelium-derived relaxing factor (nitric oxide) formation...