Document Detail


Effects of (S)-nafenodone, a new antidepressant, in isolated guinea-pig atrial and ventricular muscle fibres.
MedLine Citation:
PMID:  1893926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The electromechanical effects of a new antidepressant, (S)-nafenodone, were studied in isolated guinea-pig atrial and ventricular muscle fibres. In spontaneously beating right atria, (S)-nafenodone decreased the rate and amplitude of contractions and lengthened the sinus node recovery time. In electrically driven atria, the negative inotropic effect of (S)-nafenodone was less marked than that of imipramine and desipramine but similar to that of lofepramine. (S)-Nafenodone had no effect on the resting membrane potential but decreased the amplitude and maximum upstroke velocity (Vmax) both in atrial and ventricular muscle fibres; this effect was less marked than that produced by imipramine and desipramine. In atrial fibres, but not in ventricular fibres, (S)-nafenodone lengthened the action potential duration, but in both tissues it increased the duration of the effective refractory period out of proportion to the change in action potential duration. Moreover, it shifted the concentration-response curve for Ca2+ downwards and decreased the amplitude of the slow atrial contractions induced by histamine as well as the amplitude and Vmax of the slow action potentials induced by isoprenaline in papillary muscles. It is concluded that (S)-nafenodone exerted fewer cardiodepressant effects than imipramine and desipramine in isolated guinea-pig atrial and ventricular muscle fibres less.
Authors:
F Pérez-Vizcaino; R Carrón; E Delpón; J Tamargo
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  199     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-10-24     Completed Date:  1991-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  43-50     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects
Animals
Antidepressive Agents / pharmacology*
Calcium / pharmacology
Desipramine / pharmacology
Female
Guinea Pigs
Heart / drug effects*
Heart Atria / drug effects
Heart Ventricles / drug effects
Imipramine / pharmacology
Isoproterenol / pharmacology
Lofepramine / pharmacology
Male
Myocardial Contraction / drug effects
Naphthalenes / pharmacology*
Papillary Muscles / drug effects
Refractory Period, Electrophysiological / drug effects
Chemical
Reg. No./Substance:
0/Antidepressive Agents; 0/Naphthalenes; 23047-25-8/Lofepramine; 50-47-5/Desipramine; 50-49-7/Imipramine; 7440-70-2/Calcium; 7683-59-2/Isoproterenol; 92629-87-3/nafenodone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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