Document Detail

Effects of running and walking on osteoarthritis and hip replacement risk.
MedLine Citation:
PMID:  23377837     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Running and other strenuous sports activities are purported to increase osteoarthritis (OA) risk, more so than walking and less-strenuous activities. Analyses were therefore performed to test whether running, walking, and other exercise affect OA and hip replacement risk and to assess the role of body mass index (BMI) in mediating these relationships.
METHODS: In this article, we studied the proportional hazards analyses of patients' report of having physician-diagnosed OA and hip replacement versus exercise energy expenditure (METs).
RESULTS: Of the 74,752 runners, 2004 reported OA and 259 reported hip replacements during the 7.1-yr follow-up; whereas of the 14,625 walkers, 696 reported OA and 114 reported hip replacements during the 5.7-yr follow-up. Compared with running <1.8 MET · h · d(-1), the risks for OA and hip replacement decreased as follows: 1) 18.1% (P = 0.01) and 35.1% (P = 0.03) for the 1.8- and 3.6-MET · h · d(-1) run, respectively; 2) 16.1% (P = 0.03) and 50.4% (P = 0.002) for the 3.6- and 5.4-MET · h · d(-1) run, respectively; and 3) 15.6% (P = 0.02) and 38.5% (P = 0.01) for the ≥ 5.4-MET · h · d(-1) run, suggesting that the risk reduction mostly occurred by 1.8 MET · h · d(-1). Baseline BMI was strongly associated with both OA (5.0% increase per kilogram per square meter, P = 2 × 10(-8)) and hip replacement risks (9.8% increase per kilogram per square meter, P = 4.8 × 10(-5)), and adjustment for BMI substantially diminished the risk reduction from running ≥ 1.8 MET · h · d(-1) for OA (from 16.5%, P = 0.01, to 8.6%, P = 0.21) and hip replacement (from 40.4%, P = 0.005, to 28.5%, P = 0.07). The reductions in OA and hip replacement risk by exceeding 1.8 MET · h · d(-1) did not differ significantly between runners and walkers. Other (nonrunning) exercise increased the risk of OA by 2.4% (P = 0.009) and hip replacement by 5.0% per MET · h · d(-1) (P = 0.02), independent of BMI.
CONCLUSIONS: Running significantly reduced OA and hip replacement risk due to, in part, running's association with lower BMI, whereas other exercise increased OA and hip replacement risk.
Paul T Williams
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  45     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-18     Completed Date:  2014-02-14     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1292-7     Citation Subset:  IM; S    
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MeSH Terms
Arthroplasty, Replacement, Hip / statistics & numerical data*
Body Mass Index*
Energy Metabolism
Follow-Up Studies
Health Surveys
Middle Aged
Osteoarthritis, Hip / epidemiology,  etiology*,  prevention & control,  surgery
Proportional Hazards Models
Prospective Studies
Risk Assessment
Risk Factors
United States / epidemiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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