| Effects of Rosuvastatin versus Atorvastatin on Rho-associated Coiled-coil Containing Protein Kinase Activity and Endothelial Function in Patients with Atherosclerosis. | |
| | |
MedLine Citation:
|
PMID: 22289549 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
This randomized, double-blind, parallel-design study compared the short-term effects of rosuvastatin and atorvastatin on serum lipids and markers of inflammation and endothelial function in patients with stable atherosclerosis. Patients received either 10 mg/day rosuvastatin (n = 18) or 20 mg/day atorvastatin (n = 18), orally, for 4 weeks. Serum lipids, high-sensitivity Creactive protein (hsCRP), Rho-associated coiled-coil containing protein kinase (ROCK) activity and flow-mediated dilation (FMD) of the brachial artery were assessed before and after therapy. Both statins produced significant reductions in total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglyceride and hsCRP levels, and significant increases in FMD. Both statins significantly reduced ROCK activity and inhibition was significantly greater with rosuvastatin. There was no correlation between ROCK activity and LDL-C level in either group. There was a significant correlation between ROCK activity and FMD for both statins, but no correlations between FMD and LDL-C or hsCRP levels. Short-term treatment with either rosuvastatin or atorvastatin inhibits ROCK activity independent of cholesterol reduction, and improves endothelium dysfunction in patients with atherosclerosis. |
| | |
Authors:
|
B Liu; H M Cao; G Y Li; M Liu; J Feng; J Li; Q Wang |
Related Documents
:
|
8929609 - Resting metabolic rate is influenced by anxiety in college men. 3398799 - Comparison of reflotron and laboratory cholesterol measurements. 11277679 - Direct measurement of low-density-lipoprotein cholesterol is more effective than total ... 617329 - Serum cholesterol and triglycerides in relation to ponderal index and age in two contra... 7864269 - Low serum cholesterol level and attempted suicide. 17541579 - Development of an efficient method for screening microorganisms by using symbiotic asso... 17434319 - Effect of dietary supplementation of probiotic and vitamin c on the immune response of ... 18484969 - Dynamics of yolk sac content absorption and intestine development in ducklings fed mixt... 8934449 - Modification of membrane fatty acid composition, eicosanoid production, and phospholipa... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of international medical research Volume: 39 ISSN: 1473-2300 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2011 |
Date Detail:
|
Created Date: 2012-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
|
Languages: eng Pagination: 2314-22 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Elevated levels of immunoglobulin e may indicate steroid resistance or relapse in adult primary neph...
Next Document: Let-7c MicroRNA Expression and Clinical Significance in Hepatocellular Carcinoma.