Document Detail


Effects of Ro 15-4513 and ethanol on operant behavior of male and female C57BL/6 mice.
MedLine Citation:
PMID:  1605885     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the partial benzodiazepine receptor inverse agonist, Ro 15-4513, counteracts many ethanol effects, its effect on operant behavior or on ethanol-induced changes in this behavior, remains controversial. In this study, we examined the effects of Ro 15-4513, ethanol, and their interaction on behavior maintained by an FR 20 schedule of food reinforcement. Ro 15-4513 (1.0-4.0 mg/kg) and ethanol (1.5-3.0 g/kg) reduced lever-responding of both male and female mice. The disruptive effect of Ro 15-4513 was of short duration (approximately 10 min), and was greater in male than in female mice. Under equivalent dose and time parameters, ethanol disrupted behavior of both sexes to the same extent. In spite of the disruptive effects of both drugs when given alone, when given after ethanol and prior to testing, Ro 15-4513 attenuated the disruptive effects of ethanol in male mice. The present study extends previous reports by documenting: (1) that the disruptive effect of Ro 15-4513 on mice is of very short duration and occurs at lower doses than previously reported; (2) that, in spite of being disruptive itself, Ro 15-4513 can attenuate the disruptive effects of ethanol on schedule controlled behavior; and (3) that gender is an important consideration in determining the effects of this compound.
Authors:
K Bao; L D Middaugh; H C Becker; C L Shepherd
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Alcohol (Fayetteville, N.Y.)     Volume:  9     ISSN:  0741-8329     ISO Abbreviation:  Alcohol     Publication Date:    1992 May-Jun
Date Detail:
Created Date:  1992-07-23     Completed Date:  1992-07-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8502311     Medline TA:  Alcohol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
Affiliation:
Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston 29425-0742.
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MeSH Terms
Descriptor/Qualifier:
Animals
Azides / pharmacology*
Behavior, Animal / drug effects*
Benzodiazepines / pharmacology*
Conditioning, Operant / drug effects*
Drug Synergism
Ethanol / pharmacology*
Female
Male
Mice
Mice, Inbred C57BL
Sex Characteristics
Grant Support
ID/Acronym/Agency:
AA06611/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Azides; 12794-10-4/Benzodiazepines; 64-17-5/Ethanol; 91917-65-6/Ro 15-4513

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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