Document Detail


Effects of remote ischemic preconditioning with postconditioning in patients undergoing off-pump coronary artery bypass surgery--randomized controlled trial.
MedLine Citation:
PMID:  22301846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Myocardial injury is associated with an adverse outcome after off-pump coronary artery bypass graft surgery (OPCAB). The authors conducted a randomized controlled trial to evaluate whether remote ischemic preconditioning (RIPC) with remote ischemic postconditioning (RIPostC) reduces myocardial injury in patients undergoing OPCAB.
METHODS AND RESULTS: Seventy patients scheduled for OPCAB were randomly assigned to an RIPC+RIPostC group (n=35) or a control group (n=35). In the RIPC+RIPostC group, 4 cycles of 5-min ischemia and 5-min reperfusion were done on a lower limb before anastomoses (RIPC) and after anastomoses (RIPostC). RIPC+RIPostC significantly reduced postoperative serum troponin I levels (P=0.001). The area under the curve for postoperative troponin I was 48.7% lower in the RIPC+RIPostC group (median [interquartile range], 21.3 h·ng⁻¹·ml⁻¹, 16.5-53.1 h·ng⁻¹·ml⁻¹ vs. 41.5 h·ng⁻¹·ml⁻¹, 24.6-90.2 h·ng⁻¹·ml⁻¹, P=0.020). There was no significant difference in creatinine levels and PaO₂/F(i)O₂ ratios between the 2 groups.
CONCLUSIONS: RIPC+RIPostC by lower limb ischemia decreased postoperative myocardial enzyme elevation by almost half postoperatively in patients undergoing OPCAB.
Authors:
Deok Man Hong; Yunseok Jeon; Chang-Soon Lee; Hyun Joo Kim; Jung-Man Lee; Jae-Hyon Bahk; Ki-Bong Kim; Ho Young Hwang
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-02-03
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  76     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-27     Completed Date:  2012-06-25     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  884-90     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00889811
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers / blood
Coronary Artery Bypass, Off-Pump / adverse effects*
Coronary Artery Disease / surgery*
Creatinine / blood
Female
Humans
Ischemic Postconditioning*
Ischemic Preconditioning / methods*
Lower Extremity / blood supply*
Male
Middle Aged
Myocardial Reperfusion Injury / blood,  etiology,  prevention & control*
Republic of Korea
Time Factors
Treatment Outcome
Troponin I / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Troponin I; AYI8EX34EU/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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