| Effects of remote ischemic preconditioning with postconditioning in patients undergoing off-pump coronary artery bypass surgery--randomized controlled trial. | |
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MedLine Citation:
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PMID: 22301846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Myocardial injury is associated with an adverse outcome after off-pump coronary artery bypass graft surgery (OPCAB). The authors conducted a randomized controlled trial to evaluate whether remote ischemic preconditioning (RIPC) with remote ischemic postconditioning (RIPostC) reduces myocardial injury in patients undergoing OPCAB. Methods and Results: Seventy patients scheduled for OPCAB were randomly assigned to an RIPC+RIPostC group (n=35) or a control group (n=35). In the RIPC+RIPostC group, 4 cycles of 5-min ischemia and 5-min reperfusion were done on a lower limb before anastomoses (RIPC) and after anastomoses (RIPostC). RIPC+RIPostC significantly reduced postoperative serum troponin I levels (P=0.001). The area under the curve for postoperative troponin I was 48.7% lower in the RIPC+RIPostC group (median [interquartile range], 21.3 h·ng⁻¹·ml⁻¹, 16.5-53.1 h·ng⁻¹·ml⁻¹ vs. 41.5 h·ng⁻¹·ml⁻¹, 24.6-90.2 h·ng⁻¹·ml⁻¹, P=0.020). There was no significant difference in creatinine levels and PaO₂/F(i)O₂ ratios between the 2 groups. CONCLUSIONS: RIPC+RIPostC by lower limb ischemia decreased postoperative myocardial enzyme elevation by almost half postoperatively in patients undergoing OPCAB. |
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Authors:
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Deok Man Hong; Yunseok Jeon; Chang-Soon Lee; Hyun Joo Kim; Jung-Man Lee; Jae-Hyon Bahk; Ki-Bong Kim; Ho Young Hwang |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2012-02-03 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 76 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-03-27 Completed Date: 2012-06-25 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 884-90 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University Hospital, Seoul, Korea. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00889811 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood Coronary Artery Bypass, Off-Pump / adverse effects* Coronary Artery Disease / surgery* Creatinine / blood Female Humans Ischemic Postconditioning* Ischemic Preconditioning / methods* Lower Extremity / blood supply* Male Middle Aged Myocardial Reperfusion Injury / blood, etiology, prevention & control* Republic of Korea Time Factors Treatment Outcome Troponin I / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Troponin I; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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