Document Detail


Effects of a rehabilitation program on skeletal muscle function in idiopathic pulmonary arterial hypertension.
MedLine Citation:
PMID:  20410828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: A majority of patients with idiopathic pulmonary arterial hypertension (IPAH) display persistent exercise intolerance despite current therapies. Whether a rehabilitation program elicits favorable changes in muscle function which would partly explain improvements in exercise tolerance of IPAH patients remains unknown. We performed this study to assess the effect of a 12-week rehabilitation program on skeletal muscle characteristics and exercise tolerance in patients with IPAH.
METHODS: Exercise capacity measured by the 6-minute walk test and by the cycle endurance test (CET), limb muscle cross-sectional area, quadriceps function by maximal voluntary contraction and magnetic stimulation (potentiated twitches), and molecular muscle characteristics by quadriceps biopsy of 5 IPAH patients were assessed before and after a 12-week rehabilitation program.
RESULTS: Following training, improvements in all patients were observed for the 6-minute walk test distance, from 441 (75) to 499 (85) m, P = .01, and the CET time, from 429 (239) to 633 (380) seconds, P = .16. Minute ventilation assessed at isotime during CET decreased by 15(11)%, P = .05. This was related to both decreased carbon dioxide output and (Equation is included in full-text article.)E/(Equation is included in full-text article.)co2. These improvements were associated with decreased type IIx fiber proportion, 31(8)% to 23(10)%, P = .05.
DISCUSSION: Peripheral muscle characteristic improvements may contribute to the clinical benefit observed following a rehabilitation program in IPAH.
Authors:
Vincent Mainguy; François Maltais; Didier Saey; Philippe Gagnon; Simon Martel; Mathieu Simon; Steeve Provencher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiopulmonary rehabilitation and prevention     Volume:  30     ISSN:  1932-751X     ISO Abbreviation:  J Cardiopulm Rehabil Prev     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-09-02     Completed Date:  2011-06-02     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  101291247     Medline TA:  J Cardiopulm Rehabil Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-23     Citation Subset:  IM    
Affiliation:
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, chemin Sainte-Foy, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antihypertensive Agents / therapeutic use
Bicycling / physiology*
Exercise Test
Exercise Tolerance / physiology*
Female
Health Status Indicators
Humans
Hypertension, Pulmonary / rehabilitation
Male
Middle Aged
Muscle Contraction / physiology
Muscle, Skeletal / physiology*
Oxygen Consumption
Phosphodiesterase 5 Inhibitors / therapeutic use
Pilot Projects
Piperazines / therapeutic use
Program Evaluation
Purines / therapeutic use
Quadriceps Muscle / physiology
Sulfonamides / therapeutic use
Sulfones / therapeutic use
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Phosphodiesterase 5 Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfonamides; 0/Sulfones; 3M7OB98Y7H/sildenafil; Q326023R30/bosentan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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