| Effects of a rehabilitation program on skeletal muscle function in idiopathic pulmonary arterial hypertension. | |
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MedLine Citation:
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PMID: 20410828 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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INTRODUCTION: A majority of patients with idiopathic pulmonary arterial hypertension (IPAH) display persistent exercise intolerance despite current therapies. Whether a rehabilitation program elicits favorable changes in muscle function which would partly explain improvements in exercise tolerance of IPAH patients remains unknown. We performed this study to assess the effect of a 12-week rehabilitation program on skeletal muscle characteristics and exercise tolerance in patients with IPAH. METHODS: Exercise capacity measured by the 6-minute walk test and by the cycle endurance test (CET), limb muscle cross-sectional area, quadriceps function by maximal voluntary contraction and magnetic stimulation (potentiated twitches), and molecular muscle characteristics by quadriceps biopsy of 5 IPAH patients were assessed before and after a 12-week rehabilitation program. RESULTS: Following training, improvements in all patients were observed for the 6-minute walk test distance, from 441 (75) to 499 (85) m, P = .01, and the CET time, from 429 (239) to 633 (380) seconds, P = .16. Minute ventilation assessed at isotime during CET decreased by 15(11)%, P = .05. This was related to both decreased carbon dioxide output and (Equation is included in full-text article.)E/(Equation is included in full-text article.)co2. These improvements were associated with decreased type IIx fiber proportion, 31(8)% to 23(10)%, P = .05. DISCUSSION: Peripheral muscle characteristic improvements may contribute to the clinical benefit observed following a rehabilitation program in IPAH. |
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Authors:
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Vincent Mainguy; François Maltais; Didier Saey; Philippe Gagnon; Simon Martel; Mathieu Simon; Steeve Provencher |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiopulmonary rehabilitation and prevention Volume: 30 ISSN: 1932-751X ISO Abbreviation: J Cardiopulm Rehabil Prev Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-09-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101291247 Medline TA: J Cardiopulm Rehabil Prev Country: United States |
Other Details:
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Languages: eng Pagination: 319-23 Citation Subset: IM |
Affiliation:
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Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, chemin Sainte-Foy, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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