| Effects of red ginseng extract on visual sensitivity and ERG b-wave of bullfrog's eye. | |
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MedLine Citation:
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PMID: 19830653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the present study was to investigate the effect of red ginseng (Panax ginseng) extracts on the visual process in bullfrog's eye. The results obtained indicated that both dark-adapted and light-adapted ERG b-wave peak amplitude was increased with red ginseng treatment. Furthermore, the ERG sensitivity was elevated by 1.4 log units of light intensity. It was found that red ginseng acts as a retinal neural antagonist but not as a GABA receptor antagonist. Red ginseng improved the alcohol dehydrogenase activity and speeded up the delivery of 11 CIS-retinal from retinal pigment epithelium (RPE) to the outer disc of the photoreceptors which resulted in decreased regeneration time of rhodopsin. In the spectral scan, red ginseng treatment brings an increment in absorbance over the whole spectral range (300-800 nm) with maximum difference at around 500 nm. It is concluded that red ginseng may be used to improve visual process, and can potentially be used to treat certain ophthalmic diseases. |
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Authors:
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Fazli Wahid; Hyuk Jung; Taous Khan; Kyung-Hee Hwang; You Young Kim |
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Publication Detail:
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Type: Journal Article Date: 2009-10-14 |
Journal Detail:
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Title: Planta medica Volume: 76 ISSN: 1439-0221 ISO Abbreviation: Planta Med. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-25 Completed Date: 2010-06-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: Germany |
Other Details:
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Languages: eng Pagination: 426-32 Citation Subset: IM |
Copyright Information:
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(c) Georg Thieme Verlag KG Stuttgart . New York. |
Affiliation:
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School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Taegu, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Dehydrogenase
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metabolism Animals Electroretinography / drug effects* Eye / drug effects*, enzymology, metabolism Panax / chemistry* Photophobia / drug therapy Plant Extracts / chemistry, pharmacology*, therapeutic use Rana catesbeiana Retinal Neurons / drug effects Rhodopsin / metabolism Visual Acuity / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts; 9009-81-8/Rhodopsin; EC 1.1.1.1/Alcohol Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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