Document Detail

Effects of Raspberry Phytochemical Extract on Cell Proliferation, Apoptosis, and Serum Proteomics in a Rat Model.
MedLine Citation:
PMID:  22417609     Owner:  NLM     Status:  Publisher    
  The red raspberry extract possesses potent antioxidant capacity and anticancerous activity in vitro and in vivo. The objective of this study was to determine whether red raspberry extract affected the cell cycle, angiogenesis, and apoptosis in hepatic lesion tissues from a rat model induced by diethylnitrosamine (DEN) as well as changes of serum proteomics. Rats were treated with red raspberry extract (0.75, 1.5, or 3.0 g/kg of body weight) by gavage starting 2 h after DEN administration and continued for 20 wk. Red raspberry extract inhibited cell proliferation, vascular endothelial growth factor VEGF expression, and induced apoptosis in the hepatic lesion tissues. In addition, 2 protein peaks (2597.93 and 4513.88 m/z) were identified to differentially express in the 3.0 g/kg body weight and positive control groups by serum proteomics. These results suggest that a dietary supplement with red raspberry effectively protects against chemically induced hepatic lesions in rats.
Hong-Sheng Chen; Ming Liu; Li-Jun Shi; Jin-Lu Zhao; Chun-Peng Zhang; Luo-Qiang Lin; Yan Liu; Shu-Jun Zhang; Jun-Chao Jin; Lei Wang; Bao-Zhong Shen; Jia-Ren Liu
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Publication Detail:
Journal Detail:
Title:  Journal of food science     Volume:  76     ISSN:  1750-3841     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2012-3-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014052     Medline TA:  J Food Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  T192-T198     Citation Subset:  -    
Copyright Information:
© 2011 Institute of Food Technologists®
Authors H.-S. Chen, M. Liu, J.-L. Zhao, C.-P. Zhang, L.-Q. Lin, Y. Liu, S.-J. Zhang, J.-C.Jin, and L. Wang are with Treatment Center of Oncology, the Fourth Affiliated Hospital of Harbin Medical Univ., 37 YiYuan Street, NanGang District, Harbin 150001, P.R. China. Author L.-J. Shi is with the First Affiliated Hospital of Harbin Medical Univ., 23 You Zheng St., NanGang District, Harbin 150001, P.R. China. Author B.-Z. Shen is with Key Laboratory of Molecular Imaging in Heilongjiang, 150001, P.R. China. Author J.-R. Liu is with Public Health College, Harbin Medical Univ., 157 BaoJian Rd., NanGang District, Harbin, 150081, P.R. China. Author J.-R. Liu is currently with Harvard Medical School, 300 Longwood Ave., Boston, MA 02115, U.S.A. Direct inquiries to author J.-R. Liu (E-mail:
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