Document Detail


The effects of race on peak oxygen consumption and survival in patients with systolic dysfunction.
MedLine Citation:
PMID:  20350701     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The relationship of peak exercise oxygen consumption (VO(2)) to survival in black heart failure (HF) patients is not well established. We examined the effects of race on peak VO(2) values and survival in HF patients with systolic dysfunction. METHODS AND RESULTS: This study evaluated consecutive ambulatory HF patients who underwent symptom-limited stress tests with breath-by-breath expired gas analyses using ramped treadmill protocols. The relationship between cardiopulmonary exercise parameters and patient transplant-free survival was assessed by race. This study included 580 HF patients (mean age 52 +/- 12 years; 28% females; 22% blacks; mean left ventricular ejection fraction 26 +/- 12%; mean body mass index 28.7 +/- 5.4; 73% on beta-blocker). Black patients had a significantly lower peak VO(2) than white patients (14.2 +/- 5.2 versus 16.4 +/- 7.0; P < .0001), despite adjusting for identified covariates. However, there was no significant difference in the 1-year transplant-free survival between black and white HF patients (87% versus 85%; P = NS). Peak VO(2) was significantly associated with survival in both racial groups. CONCLUSIONS: Black HF patients had significantly lower peak VO(2), but yet had equivalent survival rates at 1 year. Further study is warranted to clarify the impact of these racial differences on the timing of cardiac transplantation black HF patients.
Authors:
Sammy Elmariah; Lee R Goldberg; Michael T Allen; Andrew Kao
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-02-09
Journal Detail:
Title:  Journal of cardiac failure     Volume:  16     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-30     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  332-9     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Inc. All rights reserved.
Affiliation:
Cardiovascular Division, Department of Medicine, The Mount Sinai School of Medicine, New York, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group* / genetics
Aged
European Continental Ancestry Group* / genetics
Exercise Test / methods
Female
Heart Failure / genetics,  mortality*,  physiopathology*
Humans
Male
Middle Aged
Oxygen Consumption / genetics,  physiology*
Survival Rate / trends
Systole / genetics,  physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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