| Effects of Quyu Xiaoban Capsule on vascular endothelial function in patients with atherosclerosis. | |
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MedLine Citation:
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PMID: 17005075 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the therapeutic effects of Quyu Xiaoban Capsule (QYXBC) on endothelial dependent vascular relaxation (EDVR) function in patients with atherosclerosis (AS) with ultrasonic technique. METHODS: Tested were the endothelial function and blood lipids of 42 patients with AS in the treated group and 30 healthy volunteers in the control group. And re-examination of these parameters was carried out on the AS patients after they had been treated with QYXBC for 10 months. RESULTS: Before treatment, the reactive hyperemia induced changes in artery diameter in the treated group was significantly lower than that in the control group (P < 0.01), while insignificant difference was found between the two groups in response to nitroglycerin. In the treated group after treatment, with D%-R improved significantly (P < 0.01), total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) decreased by 16.3%, 5.6%, 10.2% respectively and high-density lipoprotein cholesterol (HDL-C) increased by 7.5%. EDVR was correlated negatively with the serum TC, LDL-C concentrations and the baseline brachial diameter (D(0)) (r = -0.41, -0.66, -0.59, respectively, all P < 0.01), but correlated positively with HDL-C (r = 0.62, P < 0.05). The ameliorative extent of EDVR was correlated positively to the decreased magnitude of TC and LDL-C concentrations (r = 0.67, 0.59, both P < 0.01). CONCLUSION: QYXBC can lower the level of blood lipids and improve significantly EDVR function. |
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Authors:
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Yun-fang Liu; Yu-xia Zhao; Hui-ming Yu |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chinese journal of integrative medicine Volume: 12 ISSN: 1672-0415 ISO Abbreviation: Chin J Integr Med Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-28 Completed Date: 2007-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181180 Medline TA: Chin J Integr Med Country: China |
Other Details:
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Languages: eng Pagination: 171-4 Citation Subset: IM |
Affiliation:
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Department of Diagnosis, School of Medicine, Shandong University, Jinan, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brachial Artery / physiology Carotid Artery Diseases / drug therapy*, ultrasonography Cholesterol, HDL / blood Cholesterol, LDL / blood Drugs, Chinese Herbal / administration & dosage*, adverse effects Endothelium, Vascular / drug effects*, physiology* Female Humans Male Middle Aged Phytotherapy* Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Drugs, Chinese Herbal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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