Document Detail


Effects of Prudhoe Bay crude oil on hatching success and associated changes in pipping muscles in embryos of domestic chickens (Gallus gallus).
MedLine Citation:
PMID:  8722257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fertile white leghorn chicken eggs were exposed to 0, 1, 2, 4, 6, 8 or 16 microliters of Prudhoe Bay Crude oil (PBCO) on day 9 of incubation. The effects of oil on pipping and hatching success, body weight gain after hatching, serum creatine kinase levels, and pathological changes in organ systems were assessed in embryos that had survived acute toxic effects and were alive on day 18 of incubation. Exposure to oil greatly reduced pipping and hatching success. Severe edema and hemorrhage in the pipping muscle, multifocal subcapsular hepatic necrosis, marked depletion of lymphocytes in the bursa of Fabricius with infiltration by heterophils, and occasional dorso-caudal subcutaneous edema were observed in treated embryos. Pipping muscles were heavier in oil-exposed embryos. Embryos exposed to 4 microliters of PBCO had significantly reduced gain in body weight post-hatching. Serum creatine kinase levels were significantly elevated in the oil-exposed embryos only at the time of hatching. There was no evidence that exposure to oil caused degenerative changes in pipping muscle cells.
Authors:
W S Lusimbo; F A Leighton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of wildlife diseases     Volume:  32     ISSN:  0090-3558     ISO Abbreviation:  J. Wildl. Dis.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-11-25     Completed Date:  1996-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244160     Medline TA:  J Wildl Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  209-15     Citation Subset:  IM    
Affiliation:
Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chick Embryo / drug effects*,  physiology
Creatine Kinase / blood
Dose-Response Relationship, Drug
Muscles / drug effects*,  embryology,  pathology
Organ Size / drug effects
Petroleum / toxicity*
Random Allocation
Regression Analysis
Weight Gain / drug effects
Chemical
Reg. No./Substance:
0/Petroleum; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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