Document Detail


Effects of propranolol and exercise training in children with severe burns.
MedLine Citation:
PMID:  23084706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate whether propranolol administration blocks the benefits induced by exercise training in severely burned children.
STUDY DESIGN: Children aged 7-18 years (n = 58) with burns covering ≥30% of the total body surface area were enrolled in this randomized trial during their acute hospital admission. Twenty-seven patients were randomized to receive propranolol, whereas 31 served as untreated controls. Both groups participated in 12 weeks of in-hospital resistance and aerobic exercise training. Muscle strength, lean body mass, and peak oxygen consumption (VO2 peak) were measured before and after exercise training. Paired and unpaired Student t tests were used for within and between group comparisons, and χ(2) tests for nominal data.
RESULTS: Age, length of hospitalization, and total body surface area burned were similar between groups. In both groups, muscle strength, lean body mass, and VO2 peak were significantly greater after exercise training than at baseline. The percent change in VO2 peak was significantly greater in the propranolol group than in the control group (P < .05).
CONCLUSIONS: Exercise-induced enhancements in muscle mass, strength, and VO2 peak are not impaired by propranolol. Moreover, propranolol improves the aerobic response to exercise in massively burned children.
Authors:
Laura J Porro; Ahmed M Al-Mousawi; Felicia Williams; David N Herndon; Ronald P Mlcak; Oscar E Suman
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-10-17
Journal Detail:
Title:  The Journal of pediatrics     Volume:  162     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-26     Completed Date:  2013-05-16     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  799-803.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Administration, Oral
Adolescent
Age Factors
Burns / rehabilitation*,  therapy
Child
Double-Blind Method
Exercise*
Exercise Test
Exercise Therapy / methods*
Female
Hospitalization
Humans
Male
Muscle Strength / drug effects
Oxygen Consumption
Propranolol / therapeutic use*
Research Design
Grant Support
ID/Acronym/Agency:
R01 HD049471/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
9Y8NXQ24VQ/Propranolol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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