| Effects of Propranolol and Exercise Training in Children with Severe Burns. | |
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MedLine Citation:
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PMID: 23084706 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate whether propranolol administration blocks the benefits induced by exercise training in severely burned children. STUDY DESIGN: Children aged 7-18 years (n = 58) with burns covering ≥30% of the total body surface area were enrolled in this randomized trial during their acute hospital admission. Twenty-seven patients were randomized to receive propranolol, whereas 31 served as untreated controls. Both groups participated in 12 weeks of in-hospital resistance and aerobic exercise training. Muscle strength, lean body mass, and peak oxygen consumption (VO(2) peak) were measured before and after exercise training. Paired and unpaired Student t tests were used for within and between group comparisons, and χ(2) tests for nominal data. RESULTS: Age, length of hospitalization, and total body surface area burned were similar between groups. In both groups, muscle strength, lean body mass, and VO(2) peak were significantly greater after exercise training than at baseline. The percent change in VO(2) peak was significantly greater in the propranolol group than in the control group (P < .05). CONCLUSIONS: Exercise-induced enhancements in muscle mass, strength, and VO(2) peak are not impaired by propranolol. Moreover, propranolol improves the aerobic response to exercise in massively burned children. |
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Authors:
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Laura J Porro; Ahmed M Al-Mousawi; Felicia Williams; David N Herndon; Ronald P Mlcak; Oscar E Suman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-17 |
Journal Detail:
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Title: The Journal of pediatrics Volume: - ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Surgery, University of Texas Medical Branch, Galveston, TX; Shriners Hospitals for Children-Galveston, Galveston, TX. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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