| Effects of propofol and isoflurane anesthesia on the intraocular pressure and hemodynamics of pigs. | |
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MedLine Citation:
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PMID: 20714190 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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To determine the conditions under which anesthetized pigs can be used in acute noninvasive investigations of ocular hydro- and hemodynamics, the intraocular pressure (IOP) of adult pigs was recorded under the following conditions: (1) after intravenous injection of propofol plus ketamine; (2) during inhalation of isoflurane, and (3) 2 h after topical administration of bimatoprost or (4) timolol. Propofol/ketamine and isoflurane induced significant decreases in the IOP. The pulsation of the ophthalmic artery appeared at a significantly higher IOP in animals anesthetized with isoflurane than in those anesthetized with propofol/ketamine. Bimatoprost and timolol did not significantly decrease the IOP within 2 h after topical administration. It is concluded that different techniques for the acute noninvasive investigation of ocular hydro- and hemodynamics are applicable in anesthetized pigs. To test the effects of antiglaucoma agents, investigation periods longer than 2 h are required. We recommend the use of intravenous propofol/ketamine anesthesia rather than isoflurane anesthesia in future experiments using pigs. |
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Authors:
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Eva Buehner; Uta-Carolin Pietsch; Andreas Bringmann; Christian Foja; Peter Wiedemann; Susann Uhlmann |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-11 |
Journal Detail:
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Title: Ophthalmic research Volume: 45 ISSN: 1423-0259 ISO Abbreviation: Ophthalmic Res. Publication Date: 2011 |
Date Detail:
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Created Date: 2010-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0267442 Medline TA: Ophthalmic Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 42-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany. Eva.Buehner@medizin.uni-leipzig.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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