Document Detail


Effects of propofol and isoflurane anesthesia on the intraocular pressure and hemodynamics of pigs.
MedLine Citation:
PMID:  20714190     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
To determine the conditions under which anesthetized pigs can be used in acute noninvasive investigations of ocular hydro- and hemodynamics, the intraocular pressure (IOP) of adult pigs was recorded under the following conditions: (1) after intravenous injection of propofol plus ketamine; (2) during inhalation of isoflurane, and (3) 2 h after topical administration of bimatoprost or (4) timolol. Propofol/ketamine and isoflurane induced significant decreases in the IOP. The pulsation of the ophthalmic artery appeared at a significantly higher IOP in animals anesthetized with isoflurane than in those anesthetized with propofol/ketamine. Bimatoprost and timolol did not significantly decrease the IOP within 2 h after topical administration. It is concluded that different techniques for the acute noninvasive investigation of ocular hydro- and hemodynamics are applicable in anesthetized pigs. To test the effects of antiglaucoma agents, investigation periods longer than 2 h are required. We recommend the use of intravenous propofol/ketamine anesthesia rather than isoflurane anesthesia in future experiments using pigs.
Authors:
Eva Buehner; Uta-Carolin Pietsch; Andreas Bringmann; Christian Foja; Peter Wiedemann; Susann Uhlmann
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-11
Journal Detail:
Title:  Ophthalmic research     Volume:  45     ISSN:  1423-0259     ISO Abbreviation:  Ophthalmic Res.     Publication Date:  2011  
Date Detail:
Created Date:  2010-12-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0267442     Medline TA:  Ophthalmic Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  42-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Affiliation:
Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany. Eva.Buehner@medizin.uni-leipzig.de
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