Document Detail

Effects of propofol on the cardiac conduction system.
MedLine Citation:
PMID:  20659617     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: Some studies have demonstrated that the use of propofol is occasionally associated with bradyarrhythmias or reversion of arrhythmias to sinus rhythm. This property of propofol suggests interference with the Cardiac Conduction System (CCS).
CONTENTS: A review of the main contemporary articles on the use of propofol in the presence of cardiac arrhythmias was undertaken. The authors describe pathophysiological mechanisms of supraventricular tachyarrhythmias (SVT) and occasional interferences caused by propofol on the CCS.
CONCLUSIONS: The studies undertaken so far seem to indicate that propofol probably interferes in automatic SVT (at least in children), but not in reentrant tachyarrhythmias.
Paulo Warpechowski; Ari Tadeu Lírio dos Santos; Paulo José Irigon Pereira; Gustavo Glotz de Lima
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Revista brasileira de anestesiologia     Volume:  60     ISSN:  1806-907X     ISO Abbreviation:  Rev Bras Anestesiol     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-27     Completed Date:  2011-01-06     Revised Date:  2014-02-05    
Medline Journal Info:
Nlm Unique ID:  0401316     Medline TA:  Rev Bras Anestesiol     Country:  Brazil    
Other Details:
Languages:  eng; por     Pagination:  438-44     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Editora Ltda. All rights reserved.
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MeSH Terms
Anesthetics, Intravenous / pharmacology*
Heart Conduction System / drug effects*
Propofol / pharmacology*
Reg. No./Substance:
0/Anesthetics, Intravenous; YI7VU623SF/Propofol

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