Document Detail


The effects of prenatal secondhand smoke exposure on preterm birth and neonatal outcomes.
MedLine Citation:
PMID:  20919999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the relationship between prenatal secondhand smoke (SHS) exposure, preterm birth and immediate neonatal outcomes by measuring maternal hair nicotine.
DESIGN: Cross-sectional, observational design.
SETTING: A metropolitan Kentucky birthing center.
PARTICIPANTS: Two hundred and ten (210) mother-baby couplets.
METHODS: Nicotine in maternal hair was used as the biomarker for prenatal SHS exposure collected within 48 hours of birth. Smoking status was confirmed by urine cotinine analysis.
RESULTS: Smoking status (nonsmoking, passive smoking, and smoking) strongly correlated with low, medium, and high hair nicotine tertiles (ρ=.74; p<.001). Women exposed to prenatal SHS were more at risk for preterm birth (odds ratio [OR]=2.3; 95% Confidence Interval [CI] [.96, 5.96]), and their infants were more likely to have immediate newborn complications (OR=2.4; 95% CI [1.09, 5.33]) than nonexposed women. Infants of passive smoking mothers were at increased risk for respiratory distress syndrome (RDS) (OR=4.9; 95% CI [1.45, 10.5]) and admission to a Neonatal Intensive Care Unit (NICU) (OR=6.5; CI [1.29, 9.7]) when compared to infants of smoking mothers (OR=3.9; 95% CI [1.61, 14.9]; OR=3.5; 95% CI [2.09, 20.4], respectively). Passive smokers and/or women with hair nicotine levels greater than .35 ng/ml were more likely to deliver earlier (1 week), give birth to infants weighing less (decrease of 200-300 g), and deliver shorter infants (decrease of 1.1-1.7 cm).
CONCLUSIONS: Prenatal SHS exposure places women at greater risk for preterm birth, and their newborns are more likely to have RDS, NICU admissions, and immediate newborn complications.
Authors:
Kristin B Ashford; Ellen Hahn; Lynne Hall; Mary Kay Rayens; Melody Noland; James E Ferguson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG     Volume:  39     ISSN:  1552-6909     ISO Abbreviation:  J Obstet Gynecol Neonatal Nurs     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-10-05     Completed Date:  2011-02-02     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8503123     Medline TA:  J Obstet Gynecol Neonatal Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  525-35     Citation Subset:  IM; N    
Copyright Information:
© 2010 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses.
Affiliation:
College of Nursing, University of Kentucky, Lexington, KY 40536-0232, USA. kristin.ashford@uky.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers
Case-Control Studies
Cotinine / urine
Cross-Sectional Studies
Female
Hair / chemistry
Humans
Kentucky / epidemiology
Male
Maternal Exposure / adverse effects*
Nicotine / analysis
Pregnancy
Pregnancy Outcome*
Premature Birth / epidemiology,  etiology*
Regression Analysis
Smoking / adverse effects
Tobacco Smoke Pollution / adverse effects*,  analysis
Grant Support
ID/Acronym/Agency:
K12DA14040/DA/NIDA NIH HHS; M01 RR002602-22S15370/RR/NCRR NIH HHS; M01RR02602/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Tobacco Smoke Pollution; 486-56-6/Cotinine; 54-11-5/Nicotine
Comments/Corrections
Erratum In:
J Obstet Gynecol Neonatal Nurs. 2011 May;40(3):386

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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