Document Detail

Effects of pregnane glycosides on food intake depend on stimulation of the melanocortin pathway and BDNF in an animal model.
MedLine Citation:
PMID:  23308358     Owner:  NLM     Status:  MEDLINE    
Pregnane glycosides appear to modulate food intake by possibly affecting the hypothalamic feeding circuits; however, the mechanisms of the appetite-regulating effect of pregnane glycosides remain obscure. Here, we show that pregnane glycoside-enriched extracts from swamp milkweed Asclepias incarnata at 25-100 mg/kg daily attenuated food intake (up to 47.1 ± 8.5% less than controls) and body weight gain in rats (10% for males and 9% for females, respectively) by activating melanocortin signaling and inhibiting gastric emptying. The major milkweed pregnane glycoside, ikemagenin, exerted its appetite-regulating effect by decreasing levels of agouti-related protein (0.6-fold) but not NPY satiety peptides. Ikemagenin treatment also increased secretion of brain-derived neurotropic factor (BDNF) downstream of melanocortin receptors in the hypothalamus (1.4-fold) and in the C6 rat glioma cell culture in vitro (up to 6-fold). These results support the multimodal effects of pregnane glycosides on feeding regulation, which depends on the activity of the melanocortin signaling pathway and BDNF.
Slavko Komarnytsky; Debora Esposito; Thirumurugan Rathinasabapathy; Alexander Poulev; Ilya Raskin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-02-17
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  61     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-27     Completed Date:  2013-12-03     Revised Date:  2014-02-28    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1841-9     Citation Subset:  IM    
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MeSH Terms
Appetite / drug effects
Asclepias / chemistry*
Brain-Derived Neurotrophic Factor / genetics,  metabolism*
Cell Line, Tumor
Eating / drug effects*
Glycosides / administration & dosage*
Melanocortins / metabolism*
Models, Animal
Plant Extracts / administration & dosage*
Pregnanes / administration & dosage*
Rats, Wistar
Grant Support
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Glycosides; 0/Melanocortins; 0/Plant Extracts; 0/Pregnanes; 0/pregnane glycoside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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