| Effects of Pregnane Glycosides on Food Intake Depend on Stimulation of Melanocortin Pathway and BDNF in Animal Model. | |
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MedLine Citation:
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PMID: 23308358 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Pregnane glycosides appear to modulate food intake by possibly affecting the hypothalamic feeding circuits, however the mechanisms of the appetite-regulating effect of pregnane glycosides remain obscure. Here we show that pregnane glycoside-enriched extract from swamp milkweed Asclepias incarnata at 25-100 mg/kg daily attenuated food intake (up to 47.1±8.5% less than controls) and body weight gain in rats (10% for males and 9% for females, respectively) by activating melanocortin signaling and inhibiting gastric emptying. The major milkweed pregnane glycoside, ikemagenin, exerted its appetite-regulating effect by decreasing levels of agouti-related protein (0.6 fold) but not NPY satiety peptides. Ikemagenin treatment also increased secretion of brain-derived neurotropic factor (BDNF) downstream of melanocortin receptors in the hypothalamus (1.4 fold) and in the C6 rat glioma cell culture in vitro (up to 6 fold). These results support the multimodal effects of pregnane glycosides on feeding regulation, which depends on the activity of melanocortin signaling pathway and BDNF. |
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Authors:
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Slavko Komarnytsky; Debora Esposito; Thirumurugan Rathinabapathy; Alexander Poulev; Ilya Raskin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-11 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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