| Effects of pregnancy, hypertension and nitric oxide inhibition on rat uterine artery myogenic reactivity. | |
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MedLine Citation:
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PMID: 20431295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: The purpose of this study was to examine the effects of hypertension and nitric oxide (NO) inhibition on myogenic tone in uterine arteries during pregnancy. METHODS: Premyometrial radial uterine arteries from nonpregnant and late pregnant Sprague-Dawley rats were evaluated for myogenic reactivity from the following groups: control, hypertensive/NO-inhibited (L-NAME treatment) and normotensive/NO-inhibited (L-NAME plus hydralazine). RESULTS: In both nonpregnant and pregnant animals, L-NAME treatment significantly elevated blood pressures, while the addition of hydralazine made the animals normotensive. In nonpregnant animals, little myogenic tone was seen in controls; tone increased significantly in the L-NAME group, and was attenuated in those treated with L-NAME plus hydralazine. In pregnant animals, controls developed significant tone; this was reduced in the L-NAME group, and returned to control levels in the L-NAME plus hydralazine group. CONCLUSIONS: Dimensional measurements showed that arteries from the pregnant hypertensive group did not undergo expansive remodeling, suggesting that tone development is related to phenotypic alterations in vascular smooth muscle and/or altered physical forces secondary to adaptive changes in arterial diameter. These differences implicate pregnancy-specific pathways in the development and inhibition of myogenic tone, and point to potentially opposing roles of NO and hypertension. |
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Authors:
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Carolyn Barron; Maurizio Mandala; George Osol |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-04-30 |
Journal Detail:
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Title: Journal of vascular research Volume: 47 ISSN: 1423-0135 ISO Abbreviation: J. Vasc. Res. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-10-15 Completed Date: 2010-11-08 Revised Date: 2012-09-18 |
Medline Journal Info:
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Nlm Unique ID: 9206092 Medline TA: J Vasc Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 463-71 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT 05405, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Disease Models, Animal Enzyme Inhibitors / pharmacology* Female Hydralazine / pharmacology Hypertension / enzymology, physiopathology* Hypertension, Pregnancy-Induced NG-Nitroarginine Methyl Ester / pharmacology* Nitric Oxide / metabolism Nitric Oxide Synthase / antagonists & inhibitors*, metabolism Pregnancy Rats Rats, Sprague-Dawley Time Factors Uterine Artery / drug effects*, enzymology, physiopathology* Vasoconstriction / drug effects* Vasodilation / drug effects Vasodilator Agents / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL073895/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 86-54-4/Hydralazine; EC 1.14.13.39/Nitric Oxide Synthase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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