Document Detail


Effects of pregnancy, hypertension and nitric oxide inhibition on rat uterine artery myogenic reactivity.
MedLine Citation:
PMID:  20431295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: The purpose of this study was to examine the effects of hypertension and nitric oxide (NO) inhibition on myogenic tone in uterine arteries during pregnancy.
METHODS: Premyometrial radial uterine arteries from nonpregnant and late pregnant Sprague-Dawley rats were evaluated for myogenic reactivity from the following groups: control, hypertensive/NO-inhibited (L-NAME treatment) and normotensive/NO-inhibited (L-NAME plus hydralazine).
RESULTS: In both nonpregnant and pregnant animals, L-NAME treatment significantly elevated blood pressures, while the addition of hydralazine made the animals normotensive. In nonpregnant animals, little myogenic tone was seen in controls; tone increased significantly in the L-NAME group, and was attenuated in those treated with L-NAME plus hydralazine. In pregnant animals, controls developed significant tone; this was reduced in the L-NAME group, and returned to control levels in the L-NAME plus hydralazine group.
CONCLUSIONS: Dimensional measurements showed that arteries from the pregnant hypertensive group did not undergo expansive remodeling, suggesting that tone development is related to phenotypic alterations in vascular smooth muscle and/or altered physical forces secondary to adaptive changes in arterial diameter. These differences implicate pregnancy-specific pathways in the development and inhibition of myogenic tone, and point to potentially opposing roles of NO and hypertension.
Authors:
Carolyn Barron; Maurizio Mandala; George Osol
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-04-30
Journal Detail:
Title:  Journal of vascular research     Volume:  47     ISSN:  1423-0135     ISO Abbreviation:  J. Vasc. Res.     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-15     Completed Date:  2010-11-08     Revised Date:  2012-09-18    
Medline Journal Info:
Nlm Unique ID:  9206092     Medline TA:  J Vasc Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  463-71     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Affiliation:
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT 05405, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Disease Models, Animal
Enzyme Inhibitors / pharmacology*
Female
Hydralazine / pharmacology
Hypertension / enzymology,  physiopathology*
Hypertension, Pregnancy-Induced
NG-Nitroarginine Methyl Ester / pharmacology*
Nitric Oxide / metabolism
Nitric Oxide Synthase / antagonists & inhibitors*,  metabolism
Pregnancy
Rats
Rats, Sprague-Dawley
Time Factors
Uterine Artery / drug effects*,  enzymology,  physiopathology*
Vasoconstriction / drug effects*
Vasodilation / drug effects
Vasodilator Agents / pharmacology
Grant Support
ID/Acronym/Agency:
HL073895/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 86-54-4/Hydralazine; EC 1.14.13.39/Nitric Oxide Synthase
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