Document Detail


Effects and potential mechanisms of exercise training on cancer progression: a translational perspective.
MedLine Citation:
PMID:  22610066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the past decade there has been increasing research and clinical interest in the role of exercise therapy/rehabilitation as an adjunct therapy to improve symptom control and management following a cancer diagnosis. More recently, the field of 'exercise - oncology' has broadened in scope to investigate whether the benefits extend beyond symptom control to modulate cancer-specific outcomes (i.e., cancer progression and metastasis). Here we review the extant epidemiological evidence examining the association between exercise behavior, functional capacity/exercise capacity, and cancer-specific recurrence and mortality as well as all-cause mortality individuals following a cancer diagnosis. We also evaluate evidence from clinical studies investigating the effects of structured exercise on blood-based biomarkers associated with cancer progression/metastasis as well findings from preclinical investigations examining the effects and molecular mechanisms of exercise in mouse models of cancer. Current gaps in knowledge are also discussed.
Authors:
Allison S Betof; Mark W Dewhirst; Lee W Jones
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-05-17
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  30 Suppl     ISSN:  1090-2139     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-08-23     Revised Date:  2014-03-12    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S75-87     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Progression
Exercise Therapy*
Humans
Mice
Neoplasms / pathology,  therapy*
Physical Conditioning, Animal*
Prognosis
Treatment Outcome
Grant Support
ID/Acronym/Agency:
CA125458/CA/NCI NIH HHS; CA133895/CA/NCI NIH HHS; CA138634/CA/NCI NIH HHS; CA142566/CA/NCI NIH HHS; CA143254/CA/NCI NIH HHS; CA40355/CA/NCI NIH HHS; R01 CA040355/CA/NCI NIH HHS; R01 CA138624/CA/NCI NIH HHS; R01 CA142566/CA/NCI NIH HHS; R21 CA125458/CA/NCI NIH HHS; R21 CA133895/CA/NCI NIH HHS; R21 CA143254/CA/NCI NIH HHS
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