| Effects and Potential Mechanisms of Exercise Training on Cancer Progression: A Translational Perspective. | |
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MedLine Citation:
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PMID: 22610066 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Over the past decade there has been increasing research and clinical interest in the role of exercise therapy / rehabilitation as an adjunct therapy to improve symptom control and management following a cancer diagnosis. More recently, the field of 'exercise - oncology' has broadened in scope to investigate whether the benefits extend beyond symptom control to modulate cancer-specific outcomes (i.e., cancer progression and metastasis). Here we review the extant epidemiological evidence examining the association between exercise behavior, functional capacity / exercise capacity, and cancer-specific recurrence and mortality as well as all-cause mortality individuals following a cancer diagnosis. We also evaluate evidence from clinical studies investigating the effects of structured exercise on blood-based biomarkers associated with cancer progression / metastasis as well findings from preclinical investigations examining the effects and molecular mechanisms of exercise in mouse models of cancer. Current gaps in knowledge are also discussed. |
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Authors:
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Allison S Betof; Mark W Dewhirst; Lee W Jones |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-17 |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: - ISSN: 1090-2139 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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Duke Cancer Institute, Durham, North Carolina, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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