Document Detail


Effects of potassium chloride and potassium bicarbonate on endothelial function, cardiovascular risk factors, and bone turnover in mild hypertensives.
MedLine Citation:
PMID:  20083724     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the effects of potassium supplementation on endothelial function, cardiovascular risk factors, and bone turnover and to compare potassium chloride with potassium bicarbonate, we carried out a 12-week randomized, double-blind, placebo-controlled crossover trial in 42 individuals with untreated mildly raised blood pressure. Urinary potassium was 77+/-16, 122+/-25, and 125+/-27 mmol/24 hours after 4 weeks on placebo, potassium chloride, and potassium bicarbonate, respectively. There were no significant differences in office blood pressure among the 3 treatment periods, and only 24-hour and daytime systolic blood pressures were slightly lower with potassium chloride. Compared with placebo, both potassium chloride and potassium bicarbonate significantly improved endothelial function as measured by brachial artery flow-mediated dilatation, increased arterial compliance as assessed by carotid-femoral pulse wave velocity, decreased left ventricular mass, and improved left ventricular diastolic function. There was no significant difference between the 2 potassium salts in these measurements. The study also showed that potassium chloride reduced 24-hour urinary albumin and albumin:creatinine ratio, and potassium bicarbonate decreased 24-hour urinary calcium, calcium:creatinine ratio, and plasma C-terminal cross-linking telopeptide of type 1 collagen significantly. These results demonstrated that an increase in potassium intake had beneficial effects on the cardiovascular system, and potassium bicarbonate may improve bone health. Importantly, these effects were found in individuals who already had a relatively low-salt and high-potassium intake.
Authors:
Feng J He; Maciej Marciniak; Christine Carney; Nirmala D Markandu; Vidya Anand; William D Fraser; R Neil Dalton; Juan C Kaski; Graham A MacGregor
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-01-18
Journal Detail:
Title:  Hypertension     Volume:  55     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-19     Completed Date:  2010-03-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  681-8     Citation Subset:  IM    
Affiliation:
Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. f.he@qmul.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Albuminuria / drug therapy,  epidemiology,  physiopathology
Bicarbonates / administration & dosage*
Blood Pressure / drug effects
Bone Remodeling / drug effects*,  physiology
Brachial Artery / drug effects,  physiology
Calcium / urine
Cross-Over Studies
Endothelium, Vascular / drug effects*
Female
Humans
Hypertension / drug therapy*,  epidemiology,  physiopathology
Hypertrophy, Left Ventricular / drug therapy,  epidemiology,  physiopathology
Male
Middle Aged
Potassium / urine
Potassium Chloride / administration & dosage*
Potassium Compounds / administration & dosage*
Pulsatile Flow / drug effects
Risk Factors
Severity of Illness Index
Sodium Chloride, Dietary / administration & dosage
Grant Support
ID/Acronym/Agency:
FS/06/009//British Heart Foundation
Chemical
Reg. No./Substance:
0/Bicarbonates; 0/Potassium Compounds; 0/Sodium Chloride, Dietary; 298-14-6/potassium bicarbonate; 7440-09-7/Potassium; 7440-70-2/Calcium; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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