| Review article: effects of plant sterols and stanols beyond low-density lipoprotein cholesterol lowering. | |
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MedLine Citation:
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PMID: 20200328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Consumption of foods and supplements enriched with plant sterols/stanols (PS) may help reduce low-density lipoprotein cholesterol (LDL-C) levels. In this review, we consider the effects of PS beyond LDL-C lowering. Plant sterols/stanols exert beneficial effects on other lipid variables, such as apolipoprotein (apo) B/apoAI ratio and, in some studies, high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG). Plant sterols/stanols may also affect inflammatory markers, coagulation parameters, as well as platelet and endothelial function. Evidence also exists about a beneficial effect on oxidative stress, but this does not seem to be of greater degree than that expected from the LDL-C lowering. Many of these effects have been demonstrated in vitro and animal models. Some in vitro effects cannot be seen in vivo or in humans at usual doses. The epidemiological studies that evaluated the association of plasma PS concentration with cardiovascular disease (CVD) risk do not provide a definitive answer. Long-term randomized placebo-controlled studies are required to clarify the effects of supplementation with PS on CVD risk and progression of atherosclerosis. |
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Authors:
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Christos S Derdemezis; Theodosios D Filippatos; Dimitri P Mikhailidis; Moses S Elisaf |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-03-03 |
Journal Detail:
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Title: Journal of cardiovascular pharmacology and therapeutics Volume: 15 ISSN: 1940-4034 ISO Abbreviation: J. Cardiovasc. Pharmacol. Ther. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602617 Medline TA: J Cardiovasc Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 120-34 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apolipoprotein A-I / blood Apolipoproteins B / blood Atherosclerosis / metabolism, pathology, prevention & control Biological Markers / metabolism Blood Coagulation / drug effects Cardiovascular Diseases / metabolism*, prevention & control Cholesterol, HDL / blood Cholesterol, LDL / blood* Endothelium, Vascular / drug effects, metabolism Humans Inflammation / metabolism Oxidative Stress / drug effects Phytosterols / pharmacology* Platelet Aggregation / drug effects Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Apolipoproteins B; 0/Biological Markers; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Phytosterols; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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