| Effects of Pithecellobium clypearia Benth extract and its main components on inflammation and allergy. | |
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MedLine Citation:
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PMID: 19427894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ethanol extract of Pithecellobium clypearia Benth (PCE) was characterized to be rich in polyphenols by HPLC analysis, and investigated for its anti-inflammatory and anti-allergic activities. In our assay, PCE showed anti-inflammatory activity in both acute and auto-immune inflammation animal models. Administration of PCE can effectively inhibit the croton oil-induced ear edema and capillary permeability, the carrageenin-induced paw edema, and the liver injury caused by propionibacterium acnes plus lipopolysaccharide. PCE was also found to possess anti-allergic activity in inhibiting the DNFB-induced delayed hypersensitivity reaction. Meanwhile, seven main components (1-7) from PCE were studied for their effect on histamine release stimulated by compound 48/80 from rat peritoneal mast cells in vitro. Compound 2 ((-)-epigallocatechin-7-gallate), 3 ((-)-5, 7, 3', 4', 5'-pentahydroxyflavan), and 5 ((-)-tetra hydroxyflavan-7-gallate) showed significant inhibition effect on histamine release. |
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Authors:
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Li Bao; Xinsheng Yao; Jiekun Xu; Xiaoyu Guo; Hongwei Liu; Hiroshi Kurihara |
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Publication Detail:
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Type: Journal Article Date: 2009-05-08 |
Journal Detail:
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Title: Fitoterapia Volume: 80 ISSN: 1873-6971 ISO Abbreviation: Fitoterapia Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-07-20 Completed Date: 2009-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: Netherlands |
Other Details:
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Languages: eng Pagination: 349-53 Citation Subset: IM |
Affiliation:
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Key Lab of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Allergic Agents / isolation & purification, pharmacology*, therapeutic use Anti-Inflammatory Agents / isolation & purification, pharmacology*, therapeutic use Benzopyrans / isolation & purification, pharmacology* Carrageenan Catechin / analogs & derivatives*, isolation & purification, pharmacology Croton Oil Disease Models, Animal Edema / drug therapy Fabaceae / chemistry* Histamine Antagonists / isolation & purification, pharmacology Hypersensitivity / drug therapy Inflammation / drug therapy Lipopolysaccharides Liver / drug effects Male Mast Cells / drug effects Mice Molecular Structure Plant Extracts / chemistry, pharmacology*, therapeutic use Plant Leaves Plant Stems Propionibacterium acnes Rats |
| Chemical | |
Reg. No./Substance:
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0/5,7,3',4',5'-pentahydroxyflavan; 0/Anti-Allergic Agents; 0/Anti-Inflammatory Agents; 0/Benzopyrans; 0/Histamine Antagonists; 0/Lipopolysaccharides; 0/Plant Extracts; 0/gallocatechin-7-gallate; 0/tetrahydroxyflavan-7-gallate; 154-23-4/Catechin; 8001-28-3/Croton Oil; 9000-07-1/Carrageenan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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