| Effects of phenylcarboxylic acids on mitosis, endoreduplication and expression of cell cycle-related genes in roots of cucumber (Cucumis sativus L.). | |
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MedLine Citation:
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PMID: 19459009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several benzoic and cinnamic acid derivatives were identified from cucumber root exudates. The effects of these phenylcarboxylic acids on root growth and cell cycle progression were examined in germinated seeds of cucumber. All 12 phenylcarboxylic acids (0.25 mM) tested significantly inhibited cucumber radicle growth, and cinnamic acid exerted a dose-dependent inhibitory effect. At 6 h after exposure to the acids, transcript levels of the cell cycle-related genes, including two cyclin-dependent kinases (CDKs) and four cyclins were reduced. Among them, transcript of CycB, a marker gene for mitosis showed a remarkable reduction. The temporal analysis showed that expression of mitotic genes (CDKB, CycA, and CycB) were reduced throughout the experiment, while the reduction of the other genes (CDKA, CycD3;1, and CycD3;2) were observed only at earlier time points. At 48 h after treatment with benzoic and cinnamic acids, an enhancement of endoreduplication was observed. Further time course analysis indicated that endoreduplication started as early as 6 h after exposure to cinnamic acid. These results provide evidence that exposure to benzoic and cinnamic acids can induce rapid and dramatic down-regulation of cell cycle-related genes, thus leading to root growth inhibition. Meanwhile, the block of mitosis caused by phenylcarboxylic acids also induced an increased level of endoreduplication. |
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Authors:
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Yun Zhang; Min Gu; Xiaojian Xia; Kai Shi; Yanhong Zhou; Jingquan Yu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-21 |
Journal Detail:
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Title: Journal of chemical ecology Volume: 35 ISSN: 1573-1561 ISO Abbreviation: J. Chem. Ecol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-07-03 Completed Date: 2009-09-21 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7505563 Medline TA: J Chem Ecol Country: United States |
Other Details:
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Languages: eng Pagination: 679-88 Citation Subset: IM |
Affiliation:
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Department of Horticulture, Huajiachi Campus, Zhejiang University, Kaixuan Road 268, Hangzhou, 310029, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carboxylic Acids
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chemistry,
pharmacology* Cell Cycle Proteins / genetics, metabolism Cucumis sativus / drug effects, growth & development, metabolism* Cyclin-Dependent Kinases / genetics, metabolism Cyclins / genetics, metabolism Mitosis / drug effects* Plant Roots / drug effects, growth & development, metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Carboxylic Acids; 0/Cell Cycle Proteins; 0/Cyclins; EC 2.7.11.22/Cyclin-Dependent Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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