Document Detail


Effects of perianeurysmal environment during the growth of cerebral aneurysms: a case study.
MedLine Citation:
PMID:  22300939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: The natural history of cerebral aneurysms is thought to be governed by multifactorial processes involving hemodynamics, biomechanics, mechanobiology, and perianeurysmal environment. The purpose of this study was to highlight the importance of considering the influence of contacts with perianeurysmal environment structures on the hemodynamics and geometric evolution of intracranial aneurysms.
MATERIALS AND METHODS: A large aneurysm of the basilar artery in contact with bone and observed to grow during a 4-year follow-up period was selected for study. Anatomic models were constructed from longitudinal CTA images acquired at 1-year intervals during the observation period. Computational fluid dynamics simulations were carried out under pulsatile flow conditions to analyze the blood flow pattern and WSS distribution in the aneurysm during its evolution.
RESULTS: The aneurysm was observed to grow against the bone, resulting in a geometric change of the proximal parent artery, which, in turn, induced substantial changes in the aneurysm hemodynamics. In particular, a region of elevated WSS created by the inflow streams was observed to shift locations around the place where the aneurysm enlarged in contact with the bone as the aneurysm progressed. In addition, a "notch" near the distal end of the aneurysm, away from the bone and subject to relatively high WSS, was observed to grow and, later, completely disappear.
CONCLUSIONS: Contacts with perianeurysmal structures need to be considered and analyzed to assess whether they could exert a significant influence on the geometric evolution of each individual intracranial aneurysm and its hemodynamics.
Authors:
D M Sforza; C M Putman; S Tateshima; F Viñuela; J R Cebral
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-02-02
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  33     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-14     Completed Date:  2013-01-18     Revised Date:  2013-12-09    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1115-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Basilar Artery / pathology*,  physiopathology*
Blood Flow Velocity
Blood Pressure
Computer Simulation
Disease Progression
Female
Humans
Intracranial Aneurysm / pathology*,  physiopathology*
Models, Anatomic*
Models, Cardiovascular*
Models, Neurological
Grant Support
ID/Acronym/Agency:
R01 NS059063/NS/NINDS NIH HHS; R01NS059063/NS/NINDS NIH HHS
Comments/Corrections

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