| Effects of the PPAR-δ agonist MBX-8025 on atherogenic dyslipidemia. | |
| | |
MedLine Citation:
|
PMID: 22169113 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: Determine the effects of treatment with a selective PPAR-δ agonist±statin on plasma lipoprotein subfractions in dyslipidemic individuals. METHODS: Ion mobility analysis was used to measure plasma concentrations of subfractions of the full spectrum of lipoprotein particles in 166 overweight or obese dyslipidemic individuals treated with the PPAR-δ agonist MBX-8025 (50 and 100mg/d)±atorvastatin (20mg/d) in an 8-week randomized parallel arm double blind placebo controlled trial. RESULTS: MBX-8025 at both doses resulted in reductions of small plus very small LDL particles and increased levels of large LDL, with a concomitant reduction in large VLDL, and an increase in LDL peak diameter. This translated to reversal of the small dense LDL phenotype (LDL pattern B) in ∼90% of the participants. Modest increases in HDL particles were confined to the smaller HDL fractions. Atorvastatin monotherapy resulted in reductions in particles across the VLDL-IDL-LDL spectrum, with a significantly smaller reduction in small and very small LDL vs. MBX-8025 100mg/d (-24.5±5.3% vs. -47.8±4.9%), and, in combination with MBX-8025, a reversal of the increase in large LDL. CONCLUSION: PPAR-δ and statin therapies have complementary effects in improving lipoprotein subfractions associated with atherogenic dyslipidemia. |
| | |
Authors:
|
Yun-Jung Choi; Brian K Roberts; Xueyan Wang; J Casey Geaney; Sue Naim; Kathleen Wojnoonski; David B Karpf; Ronald M Krauss |
Related Documents
:
|
7085183 - The inheritance of serum cholesterol: adjustment of observed cholesterol levels for age... 1991933 - Physicians' perspectives on cholesterol and heart disease. 16770923 - Low-carbohydrate diets. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-16 |
Journal Detail:
|
Title: Atherosclerosis Volume: - ISSN: 1879-1484 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Metabolex, Inc., 3876 Bay Center Place, Hayward, CA 94545, United States. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Study on the relationship between serum 25-hydroxyvitamin D levels and vascular calcification in hem...
Next Document: A Contemporary Review of Cystic Adventitial Disease.