Document Detail

Effects of POCA on metabolism and function in the ischemic rat heart.
MedLine Citation:
PMID:  3741356     Owner:  NLM     Status:  MEDLINE    
Sodium 2-[5-(4-chlorophenyl)-pentyl]-oxirane-2-carboxylate (POCA) inhibits carnitine palmityltransferase I and fatty acid oxidation. The effects of POCA on cardiac function and on tissue levels of carnitine and coenzyme A esters were studied in the isolated rat heart subjected to 90 minutes of ischemia with and without 15 minutes of reperfusion. The perfusion medium contained 1.2 mM palmitate and 5.5 mM glucose plus or minus 0.5 mM POCA. This compound prevented accumulation of long-chain acylcarnitine and coenzyme A esters during ischemia and significantly improved the recovery of cardiac output after ischemia and reperfusion. Short-chain acylcarnitine levels were increased during ischemia by POCA. No effects were noted on tissue ATP and lactate levels. POCA may protect the ischemic heart by preventing accumulation of these toxic metabolites and by stimulating glucose utilization during ischemia.
D J Paulson; J J Noonan; K M Ward; H Stanley; A Sherratt; A L Shug
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Basic research in cardiology     Volume:  81     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1986 Mar-Apr
Date Detail:
Created Date:  1986-09-16     Completed Date:  1986-09-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  180-7     Citation Subset:  IM    
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MeSH Terms
Acyl Coenzyme A / metabolism
Adenosine Triphosphate / metabolism
Carnitine / metabolism
Coronary Circulation / drug effects
Coronary Disease / physiopathology*
Epoxy Compounds / pharmacology*
Ethers, Cyclic / pharmacology*
Hemodynamics / drug effects
Lactates / metabolism
Myocardial Contraction / drug effects
Myocardium / metabolism*
Rats, Inbred Strains
Grant Support
Reg. No./Substance:
0/Acyl Coenzyme A; 0/Epoxy Compounds; 0/Ethers, Cyclic; 0/Lactates; 541-15-1/Carnitine; 56-65-5/Adenosine Triphosphate; 78573-55-4/ethyl 2-(5-(4-chlorophenyl)pentyl)oxiran-2-carboxylate

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