Document Detail

Effects of oral contraceptives and metformin on the outcome of in vitro maturation in infertile women with polycystic ovary syndrome.
MedLine Citation:
PMID:  20113146     Owner:  NLM     Status:  MEDLINE    
METHODS: This is a retrospective study of 108 women with PCOS, subject to 152 cycles of IVM treatment. The study was held at the Reproductive Medicine Center of the First Affiliated Hospital of Wenzhou Medical College, People's Republic of China. Before entering IVM treatment, 54 patients who received oral contraceptive pill (marvelon, 0.15 mg desogestrel, and 0.03 mg ethinylestradiol), one tablet every day, and metformin 500 mg twice or three times per day were defined as the pretreated group, and another 64 patients who were not administered any drugs as the control group. The main outcome measures were the rates of oocyte maturation, fertilization, cleavage, miscarriage, clinical pregnancy, and live birth.
RESULTS: There were no significant differences between the two groups in the rates of oocyte maturation, fertilization, cleavage, and clinical pregnancy (p > 0.05). A significantly lower miscarriage rate was obtained in the pretreated group than in the control group (16.13% vs 4.0%, p < 0.01). The live birth rate per embryo transfer seemed to be higher in the pretreated group than in the control group (37.70% vs 30.38%, p = 0.363), but was not statistically significant.
CONCLUSIONS: Pretreatment with oral contraceptives and metformin improved the outcome of IVM related to the miscarriage rate and possibly also live birth rate.
Jun-Zhao Zhao; Jin-Ju Lin; Hai-Yan Yang; Wei Zhang; Xue-Feng Huang; Yin-Ping Huang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of women's health (2002)     Volume:  19     ISSN:  1931-843X     ISO Abbreviation:  J Womens Health (Larchmt)     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2012-04-10     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101159262     Medline TA:  J Womens Health (Larchmt)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-5     Citation Subset:  IM    
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MeSH Terms
Contraceptives, Oral / therapeutic use*
Fertilization in Vitro*
In Vitro Oocyte Maturation Techniques / methods*
Infertility, Female / therapy*
Menstrual Cycle / physiology
Metformin / therapeutic use*
Oocyte Retrieval / methods
Polycystic Ovary Syndrome / complications*,  physiopathology
Retrospective Studies
Sperm Injections, Intracytoplasmic / methods*
Treatment Outcome
Reg. No./Substance:
0/Contraceptives, Oral; 9100L32L2N/Metformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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