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Effects of Onion Extract on Endogenous Vascular Hydrogen Sulfide and Adrenomedulin in Atherosclerotic Rats.
MedLine Citation:
PMID:  21506909     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study aimed to examine the effect of onion extract on endogenous H2S and adrenomedulin (ADM) and on atherosclerotic progression in rats with atherosclerosis (AS). Male Sprague-Dawley rats were divided randomly into control, AS and AS+onion groups. Aortic ultrastructure and atherosclerotic lesions in aorta and coronary artery were detected. Plasma and aortic H2S were determined with a sulfide-sensitive electrode. Plasma and aortic ADM was determined with radioimmunoassay. Cystathionine-γ-lyase (CSE), calcitonin receptor-like receptor (CRLR), receptor activity-modifying protein (RAMP1, RAMP2 and RAMP3) mRNA expressions were analysed. Plasma glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), plasma malondialdehyde (MDA), nitric oxide (NO), NO synthase (NOS), aortic SOD1 and SOD2 expressions and ICAM-1 were detected. Rats in the AS group showed marked atherosclerotic lesions both in aorta and in coronary artery but decreased aortic H2S production. Decreased plasma and aortic ADM content, but increased levels of aortic CRLR, RAMP2 and RAMP3 mRNAs were observed. Plasma GSH-PX and SOD were decreased but MDA increased. Plasma ICAM-1 and NO contents and iNOS activity were increased. Onion extract, however, decreased atherosclerotic lesions and increased endogenous aortic H2S production, but decreased plasma ADM content, aortic ADM content and aortic CRLR, RAMP2 and RAMP3 mRNAs. In addition, it elevated plasma GSH-PX and SOD activities but reduced MDA; it decreased inflammatory response but increased plasma eNOS activity and NO content. Onion extract exerted a marked antiatherogenic effect in association with the up-regulation of the endogenous CSE/H2S pathway but down-regulation of the ADM/CRLR family in rats with atherosclerosis.
Authors:
Wei Li; Chaoshu Tang; Hongfang Jin; Junbao Du
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-20
Journal Detail:
Title:  Current pharmaceutical biotechnology     Volume:  -     ISSN:  1873-4316     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960530     Medline TA:  Curr Pharm Biotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. junbaodu1@126.com.
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