Document Detail

Effects of omalizumab in non-atopic asthma: results from a Spanish multicenter registry.
MedLine Citation:
PMID:  23350994     Owner:  NLM     Status:  MEDLINE    
Aim. To evaluate the effectiveness of omalizumab in non-atopic asthma. Methods. Using data from a multicenter registry of severe asthma, we evaluated and compared the clinical outcome of 29 omalizumab-treated severe non-atopic asthmatics with 266 omalizumab-treated severe allergic asthmatics. Effectiveness was assessed by considering severe exacerbations, pulmonary function, the Global Evaluation of Treatment Effectiveness (GETE) scale, and Asthma Control Test (ACT). Results. Omalizumab demonstrated significant improvement in the clinical status of non-atopic asthmatics as measured by GETE, which rose from 1.6 ± 1.1 to 2.8 ± 0.9 [corrected] at 4 months (p = .0215) to 2.9 ± 0.9 at 1 year (p = .0093) and to 3.4 ± 0.6 at 2 years (p = .0078), and by the ACT, which increased from 13.3 ± 5.5 [corrected] to 17.5 ± 5.4 at 4 months (p = .0236) to 17.9 ± 4.8 at 1 year (p = .0136) and to 20.6 ± 3.9 at 2 years (p = .0024). Forced expiratory volume in 1 second (FEV1) improved from 61.0 ± 19.4% to 65.1 ± 17.2 at 4 months to 64.1 ± 24.7 at 1 year and to 67.3 ± 23.0% [corrected] at 2 years, but without significant differences between initial and follow-up measurements (p = .52, .91, and .45, respectively) and exacerbations decreased from 3.1 ± 3.5 to 1.9 ± 2.8 at 1 year (p = .1709) to 1.8 ± 4.4 at 2 years (p = .2344). The results were not significantly different from those obtained in atopic asthmatics. Conclusion. Anti-IgE therapy can be effective in non-atopic severe asthma.
Luis Pérez de Llano; María Del Carmen Vennera; Francisco J Álvarez; Juan F Medina; Luis Borderías; Concha Pellicer; Héctor González; José A Gullón; Eva Martínez-Moragón; Carlos Sabadell; Soledad Zamarro; César Picado;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2013-01-28
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  50     ISSN:  1532-4303     ISO Abbreviation:  J Asthma     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-07     Completed Date:  2013-07-01     Revised Date:  2013-07-05    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  England    
Other Details:
Languages:  eng     Pagination:  296-301     Citation Subset:  IM    
Department of Pneumology, Hospital Xeral-Calde, Rua Doutor Ochoa, Lugo, Spain.
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MeSH Terms
Anti-Asthmatic Agents / therapeutic use*
Antibodies, Anti-Idiotypic / therapeutic use*
Antibodies, Monoclonal, Humanized / therapeutic use*
Asthma / drug therapy*,  immunology,  physiopathology
Forced Expiratory Volume / drug effects
Hypersensitivity, Immediate / drug therapy*,  immunology,  physiopathology
Immunoglobulin E / blood,  immunology
Middle Aged
Retrospective Studies
Statistics, Nonparametric
Reg. No./Substance:
0/Anti-Asthmatic Agents; 0/Antibodies, Anti-Idiotypic; 0/Antibodies, Monoclonal, Humanized; 0/omalizumab; 37341-29-0/Immunoglobulin E
Erratum In:
J Asthma. 2013 Jun;50(5):537-9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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