Document Detail

Effects of OG-VI, a nucleoside-nucleotide mixture, on ischemic myocardial metabolism in dogs.
MedLine Citation:
PMID:  9101121     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: OG-VI is a solution composed of 30 mmol/l inosine, 30 mmol/l sodium 5'-guanylate, 30 mmol/l cytidine, 22.5 mmol/l uridine, and 7.5 mmol/l thymidine, which is known to improve myocardial stunning. OBJECTIVE: To study the effect of OG-VI on myocardial energy and carbohydrate metabolism during ischemia. METHODS: Ischemia was induced in pentobarbital-anesthetized open-chested dogs for 3 min by left anterior descending coronary artery ligation. Saline, 1.2 mmol/kg per min OG-VI, or 12 mmol/kg per min OG-VI was infused at 0.1 ml/kg per min, starting 30 min before the onset of ischemia. The myocardium was extracted 3 min after the onset of ischemia, and used to determine the tissue levels of energy and carbohydrate metabolites. RESULTS: Ischemia decreased the levels of ATP and fructose 1,6 diphosphate significantly, and increased those of AMP, glucose 6 phosphate, fructose 6 phosphate and lactate. OG-VI infusion preserved the adenine nucleotide levels significantly in 3 min ischemic hearts, and attenuated the ischemia-induced alteration of carbohydrate metabolism. CONCLUSION: OG-VI may improve the myocardial metabolic derangement induced by ischemia.
Y Okazaki; S Kano; S Ogoshi; K Ichihara
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Coronary artery disease     Volume:  8     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-06-23     Completed Date:  1997-06-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
Department of Surgery II, Kochi Medical School, Nankoku, Japan.
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MeSH Terms
Carbohydrate Metabolism
Cardiotonic Agents / therapeutic use*
Energy Metabolism / drug effects
Hemodynamics / physiology
Myocardial Ischemia / drug therapy*,  metabolism,  physiopathology
Myocardium / metabolism*
Nucleosides / therapeutic use*
Nucleotides / therapeutic use*
Phosphates / metabolism
Reg. No./Substance:
0/Cardiotonic Agents; 0/Nucleosides; 0/Nucleotides; 0/OG-VI solution; 0/Phosphates

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