| Effects of OG-VI, a nucleoside-nucleotide mixture, on ischemic myocardial metabolism in dogs. | |
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MedLine Citation:
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PMID: 9101121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: OG-VI is a solution composed of 30 mmol/l inosine, 30 mmol/l sodium 5'-guanylate, 30 mmol/l cytidine, 22.5 mmol/l uridine, and 7.5 mmol/l thymidine, which is known to improve myocardial stunning. OBJECTIVE: To study the effect of OG-VI on myocardial energy and carbohydrate metabolism during ischemia. METHODS: Ischemia was induced in pentobarbital-anesthetized open-chested dogs for 3 min by left anterior descending coronary artery ligation. Saline, 1.2 mmol/kg per min OG-VI, or 12 mmol/kg per min OG-VI was infused at 0.1 ml/kg per min, starting 30 min before the onset of ischemia. The myocardium was extracted 3 min after the onset of ischemia, and used to determine the tissue levels of energy and carbohydrate metabolites. RESULTS: Ischemia decreased the levels of ATP and fructose 1,6 diphosphate significantly, and increased those of AMP, glucose 6 phosphate, fructose 6 phosphate and lactate. OG-VI infusion preserved the adenine nucleotide levels significantly in 3 min ischemic hearts, and attenuated the ischemia-induced alteration of carbohydrate metabolism. CONCLUSION: OG-VI may improve the myocardial metabolic derangement induced by ischemia. |
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Authors:
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Y Okazaki; S Kano; S Ogoshi; K Ichihara |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Coronary artery disease Volume: 8 ISSN: 0954-6928 ISO Abbreviation: Coron. Artery Dis. Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-06-23 Completed Date: 1997-06-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 39-43 Citation Subset: IM |
Affiliation:
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Department of Surgery II, Kochi Medical School, Nankoku, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbohydrate Metabolism Cardiotonic Agents / therapeutic use* Dogs Energy Metabolism / drug effects Female Hemodynamics / physiology Male Myocardial Ischemia / drug therapy*, metabolism, physiopathology Myocardium / metabolism* Nucleosides / therapeutic use* Nucleotides / therapeutic use* Phosphates / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Nucleosides; 0/Nucleotides; 0/OG-VI solution; 0/Phosphates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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