Document Detail


Effects of the novel polymer gel LeGoo on human internal thoracic arteries.
MedLine Citation:
PMID:  22115233     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Established hemostatic devices can injure vessel wall integrity. LeGoo (Pluromed, Woburn, MA), a novel poloxamer gel with reverse thermosensitive properties, is a new device for temporary occlusion of blood vessels. The present study investigated the effects of LeGoo on vascular function and morphology.
DESCRIPTION: The distal end of the human internal thoracic artery was used to assess vascular function of LeGoo-applied segments in organ bath experiments and by scanning electron microscopy.
EVALUATION: After LeGoo application, both maximal contractile responses to noradrenaline and endothelium-dependent relaxant responses to acetylcholine were significantly reduced. Scanning electron microscopy showed areas of injured endothelium with exposure of subendothelial structures being in line with the functional changes.
CONCLUSIONS: Data suggested that application of LeGoo induced significant endothelial injury and deterioration of the smooth muscle in human internal thoracic arteries.
Authors:
Bernhard Winkler; Else Müller-Schweinitzer; Faik Elezi; Thomas Grussenmeyer; Florian Rueter; Peter Matt; Moritz A Konerding; Martin T R Grapow; Friedrich S Eckstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  92     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-25     Completed Date:  2012-01-17     Revised Date:  2012-10-18    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2235-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
Affiliation:
Division of Cardiac Surgery, Heart Center Basel - Bern, University Hospital Basel, Basel, Switzerland. bwinkler@uhbs.ch
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Aged
Endothelium, Vascular / drug effects
Female
Humans
Male
Mammary Arteries / drug effects*,  pathology,  physiology
Middle Aged
Muscle, Smooth, Vascular / drug effects
Norepinephrine / pharmacology
Poloxamer / toxicity*
Chemical
Reg. No./Substance:
0/LeGoo; 106392-12-5/Poloxamer; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine
Comments/Corrections
Comment In:
Ann Thorac Surg. 2012 Aug;94(2):688; author reply 688-9   [PMID:  22818326 ]
Ann Thorac Surg. 2012 Sep;94(3):1039; author reply 1039-40   [PMID:  22916774 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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