Document Detail


Effects of a Novel Leumedin NPC 15669 on Myocardial Stunning and Preconditioned Infarction Size in Swine.
MedLine Citation:
PMID:  10603526     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: NPC is a member of the leumedins and is an inhibitor of leukocyte adhesion to endothelium via blockage of integrin binding. NPC 15669 also may have antiplatelet effects. We tested the efficacy of the novel leukocyte recruitment inhibitor NPC 15669 on myocardial stunning (MS) and preconditioned myocardial infarction (MI). Methods and Results: In an open-chested swine model, NPC 15669 (10 rng NPC/kg loading dose followed by constant infusion at 6 mg/kg/hr) was administered in six animals. Myocardial thickening (MT) was determined by epicardial ultrasound. The left anterior descending artery was occluded for 8 minutes followed by 90 minutes of reperfusion, during which myocardial MT was recorded at regular intervals. We have found that treatment with NPC 15669 increases myocardial contractility and significantly decreases MS time compared to controls (26.7 +/- 4.0 minutes vs. 50.0 +/- 4.3 minutes, p =.0026). In NPC 15669-treated animals we observed a reduction of MI size (23.4 +/- 6.7% of tissue at risk became necrotic compared to 53.0 +/- 6.6% in controls, p =.0102). Conclusions: Our data suggest that NPC 15669 significantly reduces myocardial injury in both the stunning and infarction models.
Authors:
Herzog; Gurbel; Vogel; Schlossberg; Schneider; Serebruany
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  1     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  1995  
Date Detail:
Created Date:  1999-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  163-170     Citation Subset:  -    
Affiliation:
Department of Medicine, Division of Cardiology, University of Maryland Medical Center, Baltimore, MD.
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