Document Detail

Effects of nondependent lung ventilation with continuous positive-pressure ventilation and high-frequency positive-pressure ventilation on right-ventricular function during 1-lung ventilation.
MedLine Citation:
PMID:  20870668     Owner:  NLM     Status:  In-Process    
Background. The application of volume-controlled high frequency positive pressure ventilation (HFPPV) to the nondependent lung (NL) may have comparable effects to continuous positive airway pressure (CPAP) on the right ventricular (RV) function, oxygenation, and surgical conditions during one lung ventilation (OLV) for thoracotomy. Methods. After local ethics committee approval and informed consent, 75 patients scheduled for elective thoracotomy using OLV were randomly allocated to receive nondependent lung either CPAP 2 (CPAP2; n=25) or 5 (CPAP5; n=25) cm H2O pressure setting of the device or HFPPV using VT 3 mL-1, I: E ratio <0.3 and R.R 60/min (HFPPV; n=25), followed 15 min of OLV. Intraoperative changes in RV ejection fraction (REF), end-diastolic volume (RVEDVI) and stroke work (RVSWI), stroke volume (SVI), oxygen delivery (DO2), and uptake (VO2) indices and shunt fraction (Qs: Qt) were recorded without any surgical manipulation of the lung. Results. The application of NL-HFPPV resulted in improved REF by 33%, SVI and DO2 (P < 0.01) and reduced RVEDVI, RVSWI, PVRI, oxygen uptake, and shunt fraction by 24.8% (P < 0.01) than in the NL-CPAP groups. Conclusion. We concluded that the use of NL-HFPPV is a feasible option and offers improved RV function and oxygenation during OLV for open thoracotomy.
Mohamed R El Tahan; Yasser El Ghoneimy; Mohamed Regal; Afrah Deria; Mona Al Ahmadey; Hatem El Emam
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Publication Detail:
Type:  Journal Article     Date:  2010-09-23
Journal Detail:
Title:  Seminars in cardiothoracic and vascular anesthesia     Volume:  14     ISSN:  1940-5596     ISO Abbreviation:  Semin Cardiothorac Vasc Anesth     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-01-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9807630     Medline TA:  Semin Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-300     Citation Subset:  IM    
University of Dammam, Al Khubar, Saudi Arabia.
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