Document Detail

Effects of Nidus Vespae extract and chemical fractions on the growth and acidogenicity of oral microorganisms.
MedLine Citation:
PMID:  16723116     Owner:  NLM     Status:  MEDLINE    
Nidus Vespae is the honeycomb of Polistes Olivaceous (De Geer), P. Japonicus Saussure, and Parapolybiavaria Fabricius. It is known to have a number of pharmacological effects, including antimicrobial, anti-inflammatory, anti-virus, anti-tumor and anesthetic properties. The present study evaluated the antimicrobial activity and acid inhibition properties of extracts and chemical fractions of Nidus Vespae. The raw material was first extracted using 95% ethanol/water. Subsequent fractions were prepared from this extract using cyclohexane/ethyl acetate, petroleum ether/ethyl acetate, and chloroform/methanol. For the antimicrobial activity assays, minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined using the microdilution method. The chloroform/methanol (Chl/MeOH) fraction showed the highest antibacterial activities with a MIC of 8-16mg/ml and an MBC of 16-32mg/ml. In addition, the extract and chemical fractions of Nidus Vespae showed a remarkable capacity for inhibiting the acid production of common oral bacteria at sub-MIC concentrations. Sub-MIC levels of the petroleum ether/ethyl acetate fraction significantly inhibited acid production by Streptococcus mutans ATCC 25175. The significant antiacidogenic activity demonstrated by Nidus Vespae shows it to be a promising source of novel anticariogenic agents.
Jin Xiao; Yuan Liu; Yu Ling Zuo; Ji Yao Li; Ling Ye; Xue Dong Zhou
Related Documents :
18803456 - Azelaic acid 15% gel in the treatment of rosacea.
18672936 - Concise synthesis of a pentasaccharide related to the anti-leishmanial triterpenoid sap...
16309906 - Synthesis and pharmacochemical study of novel polyfunctional molecules combining anti-i...
15996266 - Lysis with saponin improves detection of the response through cd203c and cd63 in the ba...
2217116 - A new method for purification of eimeria tenella merozoites.
22260866 - Ascorbate and dehydroascorbic acid as biomarkers of oxidative stress: validity of clini...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-24
Journal Detail:
Title:  Archives of oral biology     Volume:  51     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-22     Completed Date:  2007-06-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  804-13     Citation Subset:  D; IM    
Key Laboratory for Oral Biomedical Engineering Ministry of Education, Chengdu, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Actinomyces / drug effects
Antacids / isolation & purification,  pharmacology*
Anti-Bacterial Agents / isolation & purification,  pharmacology*
Lactobacillus / drug effects
Medicine, Chinese Traditional*
Microbial Sensitivity Tests
Streptococcus / drug effects
Reg. No./Substance:
0/Acids; 0/Antacids; 0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Characterization of the binding of the fluorescent ATP analog TNP-ATP to insulysin.
Next Document:  Template switching within exons 3 and 4 of KV11.1 (HERG) gives rise to a 5' truncated cDNA.