| The effects of newer beta-adrenoceptor antagonists on vascular function in cardiovascular disease. | |
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MedLine Citation:
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PMID: 22022769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review provides a systematic overview of the influence of the third generation beta-adrenoceptor antagonists on vascular and/or endothelial function at a cellular level as well as of the advantages of their application in hypertension, heart failure and coronary artery disease. Drugs antagonizing the beta-adrenoceptors have been in use for the treatment of hypertension for decades. In systolic heart failure and post-myocardial infarction, beta-adrenoceptor antagonists were proven to be effective in decreasing the number of deaths and improving morbidity. However, betaadrenoceptor antagonists are a heterogeneous drug group, consisting of agents with different selectivity for adrenoceptors and/or additional effects in heart and peripheral circulation. Beta-adrenoceptor antagonists comprise a multitude of different agents, which may have additional properties exceeding the pure receptor blockade. These features may provide additional benefit in the treatment of hypertension. The third generation drug nebivolol exerts a nitric oxide-mediated vasodilating activity which has positive effects on intima and media thickness and arterial rigidity, a major risk factor in cardiovascular disease. Moreover, anti-proliferative, anti-inflammatory, and anti-oxidative properties have been detected for carvedilol and nebivolol, contributing to their additional value in treatment of hypertension and heart failure. |
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Authors:
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Markus Wehland; Jirka Grosse; Ulf Simonsen; Manfred Infanger; Johann Bauer; Daniela Grimm |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current vascular pharmacology Volume: 10 ISSN: 1875-6212 ISO Abbreviation: Curr Vasc Pharmacol Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-02 Completed Date: 2012-07-27 Revised Date: 2013-05-28 |
Medline Journal Info:
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Nlm Unique ID: 101157208 Medline TA: Curr Vasc Pharmacol Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 378-90 Citation Subset: IM |
Affiliation:
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Clinic for Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke University, Magdeburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology*,
therapeutic use Animals Benzopyrans / pharmacology, therapeutic use Carbazoles / pharmacology, therapeutic use Cardiovascular Diseases / drug therapy*, physiopathology Ethanolamines / pharmacology, therapeutic use Heart Failure / drug therapy, physiopathology Humans Hypertension / drug therapy, physiopathology Nitric Oxide / metabolism Propanolamines / pharmacology, therapeutic use Risk Factors Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Benzopyrans; 0/Carbazoles; 0/Ethanolamines; 0/Propanolamines; 030Y90569U/nebivolol; 0K47UL67F2/carvedilol; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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