| Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. | |
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MedLine Citation:
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PMID: 19863351 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of polymethoxyflavonoids tangeretin and nobiletin and the related polyphenolic compounds baicalein, wogonin, quercetin, and epigallocatechin gallate on the cell growth, P-glycoprotein function, apoptosis, and cell cycle of human T lymphoblastoid leukemia MOLT-4 and its daunorubicin-resistant cells were investigated. The IC50 values of these compounds on the cell growth were 7.1-32.2 micromol/L, and the inhibitory effects were observed to be almost equal to the parent MOLT-4 and the daunorubicin-resistant cells. Tangeretin and nobiletin showed the strongest effects with the IC50 values of 7.1-14.0 micromol/L. These polymethoxyflavonoids inhibited the P-glycoprotein function and significantly influenced the cell cycle (p<.05), whereas they did not induce apoptosis. |
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Authors:
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Kimiko Ishii; Sachiko Tanaka; Keisuke Kagami; Kayo Henmi; Hiroo Toyoda; Toshikazu Kaise; Toshihiko Hirano |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer investigation Volume: 28 ISSN: 1532-4192 ISO Abbreviation: Cancer Invest. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-03-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8307154 Medline TA: Cancer Invest Country: England |
Other Details:
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Languages: eng Pagination: 220-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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drug effects* Cell Cycle / drug effects Cell Line, Tumor Cell Proliferation / drug effects Daunorubicin / pharmacology* Drug Resistance, Neoplasm Flavones / pharmacology Flavonoids / pharmacology* Humans P-Glycoprotein / antagonists & inhibitors*, physiology Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Flavones; 0/Flavonoids; 0/P-Glycoprotein; 20830-81-3/Daunorubicin; 478-01-3/nobiletin; 481-53-8/tangeretin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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