Document Detail

Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells.
MedLine Citation:
PMID:  19863351     Owner:  NLM     Status:  MEDLINE    
Effects of polymethoxyflavonoids tangeretin and nobiletin and the related polyphenolic compounds baicalein, wogonin, quercetin, and epigallocatechin gallate on the cell growth, P-glycoprotein function, apoptosis, and cell cycle of human T lymphoblastoid leukemia MOLT-4 and its daunorubicin-resistant cells were investigated. The IC50 values of these compounds on the cell growth were 7.1-32.2 micromol/L, and the inhibitory effects were observed to be almost equal to the parent MOLT-4 and the daunorubicin-resistant cells. Tangeretin and nobiletin showed the strongest effects with the IC50 values of 7.1-14.0 micromol/L. These polymethoxyflavonoids inhibited the P-glycoprotein function and significantly influenced the cell cycle (p<.05), whereas they did not induce apoptosis.
Kimiko Ishii; Sachiko Tanaka; Keisuke Kagami; Kayo Henmi; Hiroo Toyoda; Toshikazu Kaise; Toshihiko Hirano
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer investigation     Volume:  28     ISSN:  1532-4192     ISO Abbreviation:  Cancer Invest.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-03-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  220-9     Citation Subset:  IM    
Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo, Japan.
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MeSH Terms
Apoptosis / drug effects*
Cell Cycle / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Daunorubicin / pharmacology*
Drug Resistance, Neoplasm
Flavones / pharmacology
Flavonoids / pharmacology*
P-Glycoprotein / antagonists & inhibitors*,  physiology
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*,  pathology
Reg. No./Substance:
0/Flavones; 0/Flavonoids; 0/P-Glycoprotein; 20830-81-3/Daunorubicin; 478-01-3/nobiletin; 481-53-8/tangeretin

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