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Effects of natural phenolic acids on the skeletal system of ovariectomized rats.
MedLine Citation:
PMID:  19598079     Owner:  NLM     Status:  MEDLINE    
Recent reports indicate the possibility of antiresorptive and/or bone formation increasing activity of natural phenolic acids, commonly present in plants which are normally consumed in the diet. The effects of 4 natural phenolic acids (ferulic, caffeic, P-coumaric or chlorogenic, 10 mg/kg P. O. daily for 4 weeks) on the skeletal system of ovariectomized (estrogen-deficient) rats were investigated. Bone mass, mineral and calcium content, macrometric and histomorphometric parameters, and mechanical properties were examined. Phenolic acids differentially affected the skeletal system of rats with osteoporotic changes induced by the ovariectomy. Caffeic acid decreased bone mass, whereas P-coumaric acid increased the bone mass/body mass ratio and bone mineral mass/body mass ratio in the long bones, in comparison with the ovariectomized control rats. The phenolic acids improved some bone histomorphometric parameters, impaired by estrogen deficiency. However, they did not increase the ratio of bone mineral mass to bone mass, decreased by estrogen deficiency, and did not significantly affect bone mechanical properties. In conclusion, different natural phenolic acids exert differential effects on the skeletal system of ovariectomized rats, both favourable and deleterious.
Joanna Folwarczna; Maria Zych; Jan Burczyk; Hanna Trzeciak; Henryk I Trzeciak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Planta medica     Volume:  75     ISSN:  1439-0221     ISO Abbreviation:  Planta Med.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1567-72     Citation Subset:  IM    
Copyright Information:
Georg Thieme Verlag KG Stuttgart. New York.
Department of Pharmacology, Medical University of Silesia, Katowice, 41-200 Sosnowiec, Poland.
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MeSH Terms
Body Weight
Bone Density / drug effects*
Bone and Bones / drug effects*
Caffeic Acids / pharmacology,  therapeutic use
Chlorogenic Acid / pharmacology,  therapeutic use
Coumaric Acids / pharmacology,  therapeutic use
Estrogens / deficiency*
Osteoporosis / drug therapy*,  pathology
Phenols / pharmacology*,  therapeutic use
Rats, Wistar
Reg. No./Substance:
0/Caffeic Acids; 0/Coumaric Acids; 0/Estrogens; 0/Phenols; 1135-24-6/ferulic acid; 327-97-9/Chlorogenic Acid; 331-39-5/caffeic acid; 7400-08-0/4-coumaric acid

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