Document Detail

Effects of Naloxone on the Breathing Pattern of A Newborn Exposed to Maternal Opiates.
MedLine Citation:
PMID:  22372574     Owner:  NLM     Status:  Publisher    
Aim:  To give new insights into how an infant responded to naloxone, given after acquiring a maternal opiate by recording the breathing pattern directly after birth. Method:  A respiratory recording is presented of an infant during resuscitation in the delivery room after receiving naloxone for respiratory depression, resulting from maternal remifentanyl use. Results:  The infant was born apneic and bradycardic. Normal resuscitation maneuvers had no effect on the respiratory drive. Directly after administration of naloxone, a tachypneic breathing pattern with sporadic expiratory braking maneuvers was observed. Conclusion:  The immediate tachypnoea is most likely a direct effect of the naloxone causing an immediate "rebound response" after the release of the opiate induced inhibition of the respiratory drive. © 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica.
Jeroen J van Vonderen; Melissa L Siew; Stuart B Hooper; Marjon A de Boer; Frans J Walther; Arjan B Te Pas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-28
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica.
Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, the Netherlands Ritchie Center, Monash University, Melbourne, Australia Department of Obstetrics, Leiden University Medical Center, Leiden, the Netherlands.
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