Document Detail


Effects of Naloxone on the Breathing Pattern of A Newborn Exposed to Maternal Opiates.
MedLine Citation:
PMID:  22372574     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim:  To give new insights into how an infant responded to naloxone, given after acquiring a maternal opiate by recording the breathing pattern directly after birth. Method:  A respiratory recording is presented of an infant during resuscitation in the delivery room after receiving naloxone for respiratory depression, resulting from maternal remifentanyl use. Results:  The infant was born apneic and bradycardic. Normal resuscitation maneuvers had no effect on the respiratory drive. Directly after administration of naloxone, a tachypneic breathing pattern with sporadic expiratory braking maneuvers was observed. Conclusion:  The immediate tachypnoea is most likely a direct effect of the naloxone causing an immediate "rebound response" after the release of the opiate induced inhibition of the respiratory drive. © 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica.
Authors:
Jeroen J van Vonderen; Melissa L Siew; Stuart B Hooper; Marjon A de Boer; Frans J Walther; Arjan B Te Pas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-28
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica.
Affiliation:
Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, the Netherlands Ritchie Center, Monash University, Melbourne, Australia Department of Obstetrics, Leiden University Medical Center, Leiden, the Netherlands.
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