Document Detail

Effects of the NADPH oxidase p22phox C242T polymorphism on endurance exercise performance and oxidative DNA damage in response to aerobic exercise training.
MedLine Citation:
PMID:  19466604     Owner:  NLM     Status:  MEDLINE    
We examined the effects of the NADPH oxidase p22phox C242T polymorphism on endurance exercise performance and oxidative DNA damage in response to acute and chronic exercises. One hundred three subjects were recruited, among which 26 healthy subjects (CC: 12, TC: 12, and TT: 2) were studied during rest, exercise at 85% VO(2)max, and recovery before and after 8 weeks of tread-mill running. Lymphocyte DNA damage increased significantly in response to exercise (p < 0.05). There were no significant differences in plasma MDA, SOD concentrations and lymphocyte DNA damage between CC genotype and T allele group, but significant endurance training differences were observed. Endurance training increased exercise time to exhaustion in both the CC genotype and T allele groups (p < 0.05) but no significant difference was found between groups. The results of the current study with young, healthy, Korean men are interpreted to mean that 1) the majority had the CC genotype of the NADPH oxidase p22phox C242T polymorphism (82.5%: CC, 15.5%: TC, 1.9%: TT), 2) acute exercise increased lymphocyte DNA damage, 3) endurance training significantly increased exercise time to exhaustion, and alleviated lymphocyte DNA damage, and 4) The NADPH oxidase p22phox C242T polymorphism, however, did not alter lymphocyte DNA damage or exercise performance at rest, immediately after exercise, or during recovery.
Il-Young Paik; Chan-Ho Jin; Hwa-Eun Jin; Young-Il Kim; Su-Youn Cho; Hee-Tae Roh; Ah-Ram Suh; Sang-Hoon Suh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-15
Journal Detail:
Title:  Molecules and cells     Volume:  27     ISSN:  0219-1032     ISO Abbreviation:  Mol. Cells     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-12-29     Revised Date:  2010-06-16    
Medline Journal Info:
Nlm Unique ID:  9610936     Medline TA:  Mol Cells     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  557-62     Citation Subset:  IM    
Exercise Physiology Laboratory, Department of Physical Education, Yonsei University, Seoul 120-749, Korea.
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MeSH Terms
Comet Assay
DNA Damage / immunology
DNA Mutational Analysis
Exercise / physiology*
Exercise Test
Follow-Up Studies
Lymphocytes / physiology*
Malondialdehyde / metabolism
NADPH Oxidase / genetics*,  immunology,  metabolism
Oxidative Stress / physiology*
Physical Endurance / physiology*
Polymorphism, Genetic
Superoxide Dismutase / metabolism
Reg. No./Substance:
542-78-9/Malondialdehyde; EC Dismutase; EC protein, human; EC Oxidase

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