Document Detail

Effects of N-methyl-N-nitrosourethane on DNA synthesis in the guinea pig pancreas.
MedLine Citation:
PMID:  975398     Owner:  NLM     Status:  MEDLINE    
The effects of N-methyl-N-nitrosourethane (NMUT) on pancreatic DNA synthesis were investigated at sequential intervals following gavage of Hartley guinea pigs with a single dose of 30 mg/kg. There was a highly significant stimulation of DNA synthesis, as evidenced by increased incorporation of [3H] methyl-thymidine ([3H]TdR), throughout the whole pancreas and particularly in the duodenal segment, at 4 h following NMUT administration, thereafter, DNA synthesis declined sharply up to 24 h, and then recovered gradually to control levels from 24--96 h. DNA synthesis stimulated by NMUT was suppressed by hydroxyurea (HU), and hence is likely to represent replicative, rather than repair, synthesis.
Z M Iqbal; S S Epstein
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chemico-biological interactions     Volume:  15     ISSN:  0009-2797     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  131-7     Citation Subset:  IM    
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MeSH Terms
DNA Replication / drug effects*
Guinea Pigs
Nitrosomethylurethane / pharmacology*
Pancreas / drug effects,  metabolism*
Time Factors
Urethane / analogs & derivatives*
Reg. No./Substance:
51-79-6/Urethane; 615-53-2/Nitrosomethylurethane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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