| Effects of N-acetylcysteine on respiratory muscle fatigue during heavy exercise. | |
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MedLine Citation:
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PMID: 18992854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Respiratory muscle fatigue (RMF) occurs during heavy exercise in humans. N-acetylcysteine (NAC) infusion has been shown to reduce RMF, suggesting that oxidative stress is a contributing factor. The purpose of the present study was to determine the effect of an acute oral dose of NAC on RMF during heavy exercise. Subjects (n=8) were given either placebo (PLA) or NAC (1,800 mg) 45 min prior to a 30 min constant load (85V(O)(2peak)), discontinuous exercise test. Maximum respiratory pressures (inspiratory, PI(max); expiratory, PE(max)) and venous blood samples were made prior to and following each 5 min of exercise. There was no difference (p>0.05) in PI(max) between NAC (127.9+/-34.1 cm H(2)O) or PLA (134.1+/-28.1cm H(2)O) at rest. During exercise, PI(max) was significantly lower with PLA ( approximately 14%) compared to NAC at 25 and 30 min suggesting less RMF with NAC. There were no differences (p>0.05) between groups in PE(max), V(O)(2), V(E), or heart rate at rest or throughout exercise. These results suggest that an acute dose of NAC reduces RMF during heavy exercise. |
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Authors:
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Megan K Kelly; Reneé J Wicker; Thomas J Barstow; Craig A Harms |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial Date: 2008-10-17 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 165 ISSN: 1569-9048 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-26 Completed Date: 2009-03-24 Revised Date: 2009-04-08 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 67-72 Citation Subset: IM |
Affiliation:
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Department of Kinesiology, Kansas State University, 1A Natatorium, Manhattan, KS 66506, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcysteine
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pharmacology* Adult Analysis of Variance Cross-Over Studies Double-Blind Method Exercise / physiology* Free Radical Scavengers / pharmacology* Glutathione / blood Humans Male Muscle Fatigue / drug effects*, physiology Oxygen Consumption / drug effects, physiology Physical Endurance / drug effects, physiology Respiration / drug effects Respiratory Function Tests / methods Respiratory Muscles / drug effects* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Free Radical Scavengers; 616-91-1/Acetylcysteine; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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