| Effects of N-acetylcysteine on pulmonary function in patients undergoing coronary artery bypass surgery with cardiopulmonary bypass. | |
| | |
MedLine Citation:
|
PMID: 14714769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cardiopulmonary bypass (CPB) has been implicated in causing poor pulmonary gas exchange postoperatively in patients undergoing coronary artery bypass grafting (CABG) procedures. In this prospective, randomized, double-blind, placebo-controlled study, we examined the pulmonary effects of N-acetylcysteine (NAC) in patients undergoing CABG. Twenty patients undergoing elective CABG and early tracheal extubation were randomized into two groups. Group I (ten patients) received a physiologic salt solution as a placebo in a continuous intravenous infusion for one hour before CPB and 24 hours after CPB; Group II (ten patients) received 100 mg/ kg NAC intravenously for one hour before CPB and 40 mg/kg/day at 24 hours after CPB. Perioperative hemodynamic and pulmonary data were recorded. Postoperative tracheal extubation was accomplished at the earliest appropriate time. The postoperative clinical course was similar in the two groups. Both groups exhibited significant postoperative increases in A-a oxygen gradient (p < 0.01), but patients in Group II exhibited significantly lower increases in postoperative A-a oxygen gradient (p < 0.006). Other hemodynamic and pulmonary data (pulmonary capillary wedge pressure, pulmonary vascular resistance (PVR), cardiac index (CI), shunt flow, dynamic lung compliance and static lung compliance) exhibited no differences between the groups. There was no significant difference in terms of intubation time. The malondialdehyde (MDA) increase in Group II following CPB was found to be significantly lower than in Group I (p = 0.043). This clinical study reveals that administration of NAC to patients undergoing elective CABG with CPB improves systemic oxygenation. There was no effect in other pulmonary parameters and in terms of intubation time. |
| | |
Authors:
|
Nesimi Eren; Omer Cakir; Ahmet Oruc; Ziya Kaya; Levent Erdinc |
Related Documents
:
|
16534889 - Clinicopathologic characteristics of esophagectomy for esophageal carcinoma in elderly ... 17272439 - Intraoperative red blood-cell salvage in revision hip surgery. a case-matched study. 16038389 - Procalcitonin is useful whereas c-reactive protein is not, to predict complications fol... 7590499 - Intraoperative clotting factor dilution and activated hemostasis in children with ewing... 10210049 - Response to surgical stress in elderly patients and alzheimer's disease. 19342389 - Comparison of minimally invasive closed circuit versus standard extracorporeal circulat... 23140129 - Prospective randomized study of cervical arthroplasty and anterior cervical discectomy ... 23152259 - Omentoplasty for esophagogastrostomy after esophagectomy. 16534889 - Clinicopathologic characteristics of esophagectomy for esophageal carcinoma in elderly ... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Perfusion Volume: 18 ISSN: 0267-6591 ISO Abbreviation: Perfusion Publication Date: 2003 Nov |
Date Detail:
|
Created Date: 2004-01-12 Completed Date: 2005-04-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8700166 Medline TA: Perfusion Country: England |
Other Details:
|
Languages: eng Pagination: 345-50 Citation Subset: IM |
Affiliation:
|
Department of Thoracic and Cardiovascular Surgery, Dicle University, School of Medicine, Diyarbakir, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcysteine
/
therapeutic use* Cardiopulmonary Bypass* Coronary Artery Bypass* Double-Blind Method Female Humans Lipid Peroxidation Male Middle Aged Placebos Prospective Studies Pulmonary Gas Exchange / drug effects* Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
|
0/Placebos; 616-91-1/Acetylcysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Measurement of systemic carbon dioxide production during cardiopulmonary bypass: a comparison of Fic...
Next Document: Importance of internal mammary artery perfusion in cardiac ischemia and reperfusion.